Oe Kenichi, Jingushi Seiya, Iida Hirokazu, Tomita Naohide
Department of Orthopaedic Surgery, Kansai Medical University, Osaka, Japan.
Biomed Mater Eng. 2013;23(5):329-38. doi: 10.3233/BME-130757.
The purpose of this study was to assess the removability and biological reactivity of an ultrahigh molecular weight polyethylene (UHMWPE) fiber cable as a new biomaterial for osteosynthesis. We used a pull-out test and an implantation test to analyze the performance of the UHMWPE fiber cable using a dog model, and compared its characteristics with those of a wire cable and a soft wire. In the pull-out test, the UHMWPE fiber cable was as easy to remove as the soft wire, and both the UHMWPE fiber cable and the soft wire were significantly easier to remove than the wire cable. The fixation capability and the biological reactivity of the UHMWPE fiber cable were examined in an osteosynthesis model of the dog greater trochanter, and were compared with those of the soft wire. The bone union rate, assessed radiographically, was very similar when using the UHMWPE fiber cable and the soft wire. However, in the soft wire group, both the surface of the greater trochanter under the fixation material and the penetration area around the fixation material showed an increased tendency toward a biological reaction, including inflammation and granulation tissue formation, as compared to the UHMWPE fiber cable group. The UHMWPE fiber cable was as easily removed from the bone tissue as the soft wire, and was easier to remove than the wire cable. Additionally, the UHMWPE fiber cable caused reduced biological reactivity with the surrounding tissue, as compared with the soft wire. In conclusion, the UHMWPE fiber cable appeared to be a suitable fixation material for osteosynthesis.
本研究的目的是评估超高分子量聚乙烯（UHMWPE）纤维缆绳作为一种新型骨合成生物材料的可移除性和生物反应性。我们采用拔出试验和植入试验，利用犬模型分析UHMWPE纤维缆绳的性能，并将其特性与钢丝绳和软金属丝进行比较。在拔出试验中，UHMWPE纤维缆绳与软金属丝一样易于移除，并且UHMWPE纤维缆绳和软金属丝都比钢丝绳明显更容易移除。在犬大转子骨合成模型中检查了UHMWPE纤维缆绳的固定能力和生物反应性，并与软金属丝进行比较。通过影像学评估，使用UHMWPE纤维缆绳和软金属丝时骨愈合率非常相似。然而，与UHMWPE纤维缆绳组相比，在软金属丝组中，固定材料下方的大转子表面以及固定材料周围的穿透区域显示出生物反应增加的趋势，包括炎症和肉芽组织形成。UHMWPE纤维缆绳与软金属丝一样易于从骨组织中移除，并且比钢丝绳更容易移除。此外，与软金属丝相比，UHMWPE纤维缆绳与周围组织的生物反应性降低。总之，UHMWPE纤维缆绳似乎是一种适合骨合成的固定材料。
