2010-2012 年侵袭性感染中化脓性链球菌大环内酯类和氟喹诺酮类耐药与分子分型的相关性。
Associations of macrolide and fluoroquinolone resistance with molecular typing in Streptococcus pyogenes from invasive infections, 2010-2012.
机构信息
Laboratory of Molecular Epidemiology for Infectious Agents, Kitasato Institute for Life Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan.
出版信息
Int J Antimicrob Agents. 2013 Nov;42(5):447-9. doi: 10.1016/j.ijantimicag.2013.06.022. Epub 2013 Aug 9.
In this study, the relationship between emm type and antibiotic resistance in 283 invasive group A streptococcal strains collected during surveillance from 2010 to 2012 was analysed. Strains were characterised by emm typing, multilocus sequence typing and antimicrobial susceptibility. Resistance rates for macrolide antibiotics conferred by mef(A), erm(A) or erm(B) were high (54.4%). The most prevalent (40.3%) macrolide resistance mediated by mef(A) was present in 92.2% of emm1 strains. It was found that 53.3% of emm12 strains and 91.7% of emm28 strains had erm(A) or erm(B) genes. Intermediate resistance to fluoroquinolones caused by a mutation in parC was found in 14.1% of strains. Furthermore, three strains (1.1%) with high resistance caused by mutations in both parC and gyrA were detected. Fluoroquinolone resistance was present in various emm types.
本研究分析了 2010 年至 2012 年监测期间采集的 283 株侵袭性 A 组链球菌中 emm 型与抗生素耐药性之间的关系。通过 emm 分型、多位点序列分型和抗菌药物敏感性试验对菌株进行了特征分析。mef(A)、erm(A)或 erm(B)介导的大环内酯类抗生素耐药率较高（54.4%）。最常见（40.3%）的由 mef(A)介导的大环内酯类耐药性存在于 92.2%的 emm1 菌株中。发现 53.3%的 emm12 菌株和 91.7%的 emm28 菌株存在 erm(A)或 erm(B)基因。14.1%的菌株存在 parC 突变引起的氟喹诺酮类药物中介耐药。此外，还检测到 3 株（1.1%）因 parC 和 gyrA 同时突变引起的高度耐药菌株。氟喹诺酮类耐药存在于各种 emm 型中。
Zotero 插件