Li Rui-yan, Cao Zhi-gang, Li Ying, Wang Rui-tao
Department of Neurosurgery, The Second Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang, China.
Department of Interventional Radiology, The Second Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang, China.
Clin Hemorheol Microcirc. 2015;59(4):301-7. doi: 10.3233/CH-131760.
The presence of silent cerebral infarction (SCI) increases the risk of transient ischemia attack, symptomatic stroke, cardiovascular disease and dementia. Increased viscosity is associated with aging, obesity, carotid intima-media thickness, metabolic syndrome, hypertension, diabetes, ischemic heart disease, and stroke.
The purpose of the study was to assess the hemorheological parameters levels in SCI patients.
A cross-sectional study was conducted to evaluate the association between hemorheological parameters and SCI in 1487 subjects (868 men and 619 women) undergoing medical check-up.
The participants with SCI had higher whole blood viscosity (WBV) levels at low shear rate than those without SCI (10.34 ± 1.77 mPa.s vs. 8.98 ± 0.88 mPa.s; P < 0.001). Moreover, the subjects with a high WBV had a higher prevalence of SCI. Logistic regression analysis revealed that a significant association of WBV levels with the risk of SCI after adjustment for confounding factors (OR: 2.025; 95% CI: 1.750-2.343; P < 0.001).
Whole blood viscosity at low shear rate is a novel indicator for SCI regardless of classical cardiovascular risk factors. Early measurement of whole blood viscosity may be helpful to assess the risk of stroke.
无症状性脑梗死（SCI）的存在会增加短暂性脑缺血发作、症状性中风、心血管疾病和痴呆的风险。血液粘度增加与衰老、肥胖、颈动脉内膜中层厚度、代谢综合征、高血压、糖尿病、缺血性心脏病和中风有关。
本研究的目的是评估SCI患者的血液流变学参数水平。
进行了一项横断面研究，以评估1487名接受体检的受试者（868名男性和619名女性）的血液流变学参数与SCI之间的关联。
患有SCI的参与者在低剪切率下的全血粘度（WBV）水平高于未患SCI的参与者（10.34±1.77毫帕·秒对8.98±0.88毫帕·秒；P<0.001）。此外，WBV高的受试者SCI患病率更高。逻辑回归分析显示，在调整混杂因素后，WBV水平与SCI风险存在显著关联（OR：2.025；95%CI：1.750-2.343；P<0.001）。
无论经典心血管危险因素如何，低剪切率下的全血粘度都是SCI的一个新指标。早期测量全血粘度可能有助于评估中风风险。
