From the Departments of Neurosurgery (R.-Y.L.), Interventional Radiology (Z.-G.C.), and Geriatrics (J.-R.Z., Y.L., R.-T.W.) and International Physical Examination and Healthy Center (Y.L.), the Second Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang, China.
Arterioscler Thromb Vasc Biol. 2014 Apr;34(4):946-51. doi: 10.1161/ATVBAHA.113.303003. Epub 2013 Dec 26.
The presence of silent cerebral infarction (SCI) increases the risk of transient ischemia attack, symptomatic stroke, cardiovascular disease, and dementia. Total bilirubin (TB) levels were demonstrated to be decreased in carotid intima-media thickness, cardiovascular disease, stroke, and peripheral arterial disease. However, little information is available concerning the correlation between TB and SCI.
A cross-sectional study was conducted to evaluate the association between TB and SCI in 2865 subjects (1831 men and 1034 women) undergoing medical checkup. The participants with SCI had lower TB levels than those without SCI. The subjects with a low TB had a higher prevalence of SCI. Moreover, partial correlation showed that TB levels were tightly correlated with brachial-ankle pulse wave velocity after adjusting for confounding covariates (r=-0.149; P<0.001). Multivariate logistic regression analysis revealed that higher TB was associated with a lower risk of SCI (odds ratio, 0.925; 95% confidence interval, 0.897-0.954; P<0.001).
TB is a novel biochemical indicator for SCI regardless of classical cardiovascular risk factors. Early measurement of TB may be useful to assess the risk of SCI.
无症状性脑梗死（SCI）的存在会增加短暂性脑缺血发作、症状性中风、心血管疾病和痴呆的风险。总胆红素（TB）水平在颈动脉内膜中层厚度、心血管疾病、中风和外周动脉疾病中均有所降低。然而，关于 TB 与 SCI 之间的相关性，相关信息却很少。
本研究对 2865 名接受体检的受试者（1831 名男性和 1034 名女性）进行了横断面研究，以评估 TB 与 SCI 之间的相关性。患有 SCI 的受试者的 TB 水平低于无 SCI 的受试者。TB 水平较低的受试者 SCI 的患病率更高。此外，偏相关分析显示，在校正混杂因素后，TB 水平与肱踝脉搏波速度密切相关（r=-0.149；P<0.001）。多变量 logistic 回归分析显示，TB 水平升高与 SCI 风险降低相关（比值比，0.925；95%置信区间，0.897-0.954；P<0.001）。
无论是否存在经典心血管危险因素，TB 都是 SCI 的一个新的生化指标。早期测量 TB 可能有助于评估 SCI 的风险。
