Department of Food and Beverage Management, NanKai University of Technology, Nan-Tou County, Taiwan, ROC.
In Vivo. 2013 Sep-Oct;27(5):623-6.
A number of experiments have demonstrated that benzyl-isothiocyanate (BITC) induces cytotoxic cell death through the induction of apoptosis in various human cancer cell lines. In the present study, we investigated the effects of BITC on the growth of A375.S2 cell xenograft tumors in nude BALB/c mice in vivo. The A375.S2 cancer cells were inoculated subcutaneously into the lower flanks of each nude mouse. After cancer cell inoculation, all animals were maintained in the animal room for seven days and all mice produced one palpable tumor. Animals were randomly divided into two groups, each mouse was individually given intraperitoneal injections of BITC (20 mg/kg) or not (control). Results from the in vivo experiments indicated that BITC did not significantly affect the body weight of nude BALB/c mice bearing xenograft A375.S2 cell tumors but did significantly decrease the tumor weight.
许多实验已经证明，苄基异硫氰酸酯（BITC）通过诱导各种人癌细胞系中的细胞凋亡诱导细胞毒性细胞死亡。在本研究中，我们研究了 BITC 对裸鼠皮下接种 A375.S2 细胞异种移植瘤生长的影响。将 A375.S2 癌细胞皮下接种到每只裸鼠的下侧。癌细胞接种后，所有动物均在动物室中饲养七天，所有小鼠均产生一个可触及的肿瘤。动物随机分为两组，每组小鼠分别腹腔注射 BITC（20mg/kg）或不注射（对照）。体内实验结果表明，BITC 对携带异种移植 A375.S2 细胞肿瘤的裸鼠的体重没有显著影响，但显著降低了肿瘤重量。
