Mitsiogianni Melina, Koutsidis Georgios, Mavroudis Nikos, Trafalis Dimitrios T, Botaitis Sotiris, Franco Rodrigo, Zoumpourlis Vasilis, Amery Tom, Galanis Alex, Pappa Aglaia, Panayiotidis Mihalis I
Department of Applied Sciences, Northumbria University, Newcastle Upon Tyne NE1 8ST, UK.
Department of Food and Nutritional Sciences, University of Reading, Reading RG6 6AP, UK.
Antioxidants (Basel). 2019 Apr 18;8(4):106. doi: 10.3390/antiox8040106.
Many studies have shown evidence in support of the beneficial effects of phytochemicals in preventing chronic diseases, including cancer. Among such phytochemicals, sulphur-containing compounds (e.g., isothiocyanates (ITCs)) have raised scientific interest by exerting unique chemo-preventive properties against cancer pathogenesis. ITCs are the major biologically active compounds capable of mediating the anticancer effect of cruciferous vegetables. Recently, many studies have shown that a higher intake of cruciferous vegetables is associated with reduced risk of developing various forms of cancers primarily due to a plurality of effects, including (i) metabolic activation and detoxification, (ii) inflammation, (iii) angiogenesis, (iv) metastasis and (v) regulation of the epigenetic machinery. In the context of human malignant melanoma, a number of studies suggest that ITCs can cause cell cycle growth arrest and also induce apoptosis in human malignant melanoma cells. On such basis, ITCs could serve as promising chemo-therapeutic agents that could be used in the clinical setting to potentiate the efficacy of existing therapies.
许多研究已证明植物化学物质在预防包括癌症在内的慢性疾病方面具有有益作用。在这类植物化学物质中，含硫化合物（如异硫氰酸盐（ITCs））因其对癌症发病机制具有独特的化学预防特性而引起了科学界的关注。ITCs是能够介导十字花科蔬菜抗癌作用的主要生物活性化合物。最近，许多研究表明，摄入较多十字花科蔬菜与多种癌症的发病风险降低有关，这主要归因于多种效应，包括（i）代谢激活和解毒，（ii）炎症，（iii）血管生成，（iv）转移以及（v）表观遗传机制的调节。在人类恶性黑色素瘤方面，多项研究表明ITCs可导致细胞周期生长停滞，并诱导人类恶性黑色素瘤细胞凋亡。基于此，ITCs有望成为有前景的化学治疗剂，可在临床环境中用于增强现有疗法的疗效。
