Second Department of Psychiatry, Medical School, University of Athens, Attikon University General Hospital, Athens, Greece.
In Vivo. 2013 Sep-Oct;27(5):651-3.
Acute eosinophilic pneumonia (AEP) is a severe syndrome which can be induced for many reasons, including drugs. AEP has rarely been associated with first-generation antipsychotics and never been reported after use of second-generation antipsychotics, such as risperidone.
We report a case of a 64-year-old man with a medical history of alchoholism and paranoid symptoms, treated with risperidone at low doses. Following risperidone medication, he presented with respiratory distress. Bronchoalveolar lavage (BAL) specimen was indicated of AEP. All evidence indicated risperidone as the most probable causal factor. The syndrome rapidly resolved after discontinuation of the drug.
Pathophysiological mechanisms implicated in the development of AEP in our patient seem to be associated with eotaxin and serotonin eosinophilic-specific chemoattracting action, through the serotoninergic action of risperidone.
To our knowledge, this is the first case report of a clinical adverse reaction of AEP from an atypical antipsychotic agent (risperidone).
急性嗜酸性粒细胞肺炎（AEP）是一种严重的综合征，可由多种原因引起，包括药物。AEP 很少与第一代抗精神病药相关，也从未在使用第二代抗精神病药（如利培酮）后报告过。
我们报告了一例 64 岁男性的病例，该患者有酗酒和偏执症状病史，曾接受低剂量利培酮治疗。在使用利培酮后，他出现呼吸窘迫。支气管肺泡灌洗（BAL）标本提示为 AEP。所有证据均表明利培酮是最可能的致病因素。停药后综合征迅速缓解。
我们患者中发生 AEP 的病理生理机制似乎与嗜酸粒细胞趋化因子和 5-羟色胺嗜酸性粒细胞特异性趋化作用有关，这与利培酮的 5-羟色胺能作用有关。
据我们所知，这是首例由非典型抗精神病药物（利培酮）引起的 AEP 临床不良反应的病例报告。
