遗传性淀粉样变性脑出血——荷兰型。锝-99m六甲基丙烯胺肟单光子发射计算机断层扫描。

Hereditary cerebral hemorrhage with amyloidosis--Dutch type. Tc-99m HM-PAO single photon emission computed tomography.

作者信息

Haan J, van Kroonenburgh M J, Algra P R, Buruma O J, Pauwels E K, Bloem B R, Roos R A

机构信息

Department of Neurology, University Hospital Leiden, The Netherlands.

出版信息

Neuroradiology. 1990;32(2):142-5. doi: 10.1007/BF00588564.

DOI:10.1007/BF00588564

PMID:2398939

Abstract

We performed single photon emission computed tomography (SPECT) and cerebral CT-scans in nine patients with hereditary cerebral amyloid angiopathy. CT-scans showed 23 focal hypodense lesions, 13 of which were visible on SPECT as a CBF-defect. One patient showed a CBF-defect on SPECT without CT-scan lesion and had a cerebral hemorrhage three months later in that particular region. In two additional patients, who were 50% at risk for this autosomal dominant disease, CBF-defects on SPECT, but no cortical lesions on CT-scan were found. CT-scans may be more sensitive than SPECT to detect chronic lesions caused by cerebral hemorrhages, but another possibility is that hemorrhages do not always lead to persistent CBF-defects. SPECT can show the effect of amyloid deposits on CBF before the angiopathy causes clinical symptoms.

摘要

我们对9例遗传性脑淀粉样血管病患者进行了单光子发射计算机断层扫描（SPECT）和脑部CT扫描。CT扫描显示有23个局灶性低密度病变，其中13个在SPECT上表现为脑血流量（CBF）缺损。1例患者SPECT显示CBF缺损，但CT扫描未见病变，3个月后该特定区域发生脑出血。另外2例有50%患这种常染色体显性疾病风险的患者，SPECT显示CBF缺损，但CT扫描未发现皮质病变。CT扫描在检测脑出血引起的慢性病变方面可能比SPECT更敏感，但另一种可能性是出血并不总是导致持续性CBF缺损。SPECT可以在血管病引起临床症状之前显示淀粉样沉积物对CBF的影响。