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Plant Signal Behav. 2013 Nov;8(11):e26115. doi: 10.4161/psb.26115. Epub 2013 Aug 29.
2
Saccharomyces cerevisiae FKBP12 binds Arabidopsis thaliana TOR and its expression in plants leads to rapamycin susceptibility.酿酒酵母FKBP12与拟南芥TOR结合，其在植物中的表达导致对雷帕霉素敏感。
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3
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Physiological function of FKBP12, a primary target of rapamycin/FK506: a newly identified role in transcription of ribosomal protein genes in yeast.FKBP12 的生理功能，雷帕霉素/ FK506 的主要靶点：在酵母核糖体蛋白基因转录中的新作用。
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Rapamycin exerts antifungal activity in vitro and in vivo against Mucor circinelloides via FKBP12-dependent inhibition of Tor.雷帕霉素通过FKBP12依赖性抑制Tor在体外和体内对卷枝毛霉发挥抗真菌活性。
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Rapamycin blocks sexual development in fission yeast through inhibition of the cellular function of an FKBP12 homolog.雷帕霉素通过抑制FKBP12同源物的细胞功能来阻断裂殖酵母的性发育。
J Biol Chem. 2001 Jul 6;276(27):24736-42. doi: 10.1074/jbc.M102090200. Epub 2001 May 2.
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Secretion of FK506/FK520 and rapamycin by Streptomyces inhibits the growth of competing Saccharomyces cerevisiae and Cryptococcus neoformans.链霉菌分泌的FK506/FK520和雷帕霉素可抑制竞争酵母和新型隐球菌的生长。
Microbiology (Reading). 1999 Aug;145 ( Pt 8):1989-2000. doi: 10.1099/13500872-145-8-1989.
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Rapamycin and less immunosuppressive analogs are toxic to Candida albicans and Cryptococcus neoformans via FKBP12-dependent inhibition of TOR.雷帕霉素及免疫抑制性较低的类似物通过FKBP12依赖的TOR抑制作用，对白色念珠菌和新型隐球菌具有毒性。
Antimicrob Agents Chemother. 2001 Nov;45(11):3162-70. doi: 10.1128/AAC.45.11.3162-3170.2001.

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本文引用的文献

1
Target of rapamycin signaling regulates metabolism, growth, and life span in Arabidopsis.雷帕霉素靶蛋白信号通路调控拟南芥的代谢、生长和寿命。
Plant Cell. 2012 Dec;24(12):4850-74. doi: 10.1105/tpc.112.107144. Epub 2012 Dec 28.
2
Target of rapamycin regulates development and ribosomal RNA expression through kinase domain in Arabidopsis.雷帕霉素靶蛋白通过激酶结构域调控拟南芥的发育和核糖体 RNA 的表达。
Plant Physiol. 2011 Mar;155(3):1367-82. doi: 10.1104/pp.110.169045. Epub 2011 Jan 25.
3
Expansion of the target of rapamycin (TOR) kinase family and function in Leishmania shows that TOR3 is required for acidocalcisome biogenesis and animal infectivity.雷帕霉素靶蛋白（TOR）激酶家族在利什曼原虫中的扩增及其功能表明，TOR3 对于液泡（酸钙）小体的生物发生和动物感染性是必需的。
Proc Natl Acad Sci U S A. 2010 Jun 29;107(26):11965-70. doi: 10.1073/pnas.1004599107. Epub 2010 Jun 15.
4
The TOR pathway modulates the structure of cell walls in Arabidopsis.TOR 途径调节拟南芥细胞壁的结构。
Plant Cell. 2010 Jun;22(6):1898-908. doi: 10.1105/tpc.109.073007. Epub 2010 Jun 8.
5
Extending healthy life span--from yeast to humans.延长健康寿命——从酵母到人类。
Science. 2010 Apr 16;328(5976):321-6. doi: 10.1126/science.1172539.
6
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice.在生命后期喂食雷帕霉素可延长基因异质小鼠的寿命。
Nature. 2009 Jul 16;460(7253):392-5. doi: 10.1038/nature08221. Epub 2009 Jul 8.
7
Saccharomyces cerevisiae FKBP12 binds Arabidopsis thaliana TOR and its expression in plants leads to rapamycin susceptibility.酿酒酵母FKBP12与拟南芥TOR结合，其在植物中的表达导致对雷帕霉素敏感。
BMC Plant Biol. 2007 Jun 1;7:26. doi: 10.1186/1471-2229-7-26.
8
TOR signaling in growth and metabolism.生长与代谢中的TOR信号传导
Cell. 2006 Feb 10;124(3):471-84. doi: 10.1016/j.cell.2006.01.016.
9
Arabidopsis TARGET OF RAPAMYCIN interacts with RAPTOR, which regulates the activity of S6 kinase in response to osmotic stress signals.拟南芥雷帕霉素靶蛋白与 Raptor 相互作用，Raptor 在响应渗透胁迫信号时调节 S6 激酶的活性。
Plant Cell. 2006 Feb;18(2):477-90. doi: 10.1105/tpc.105.035931. Epub 2005 Dec 23.
10
mTOR-targeted therapy of cancer with rapamycin derivatives.用雷帕霉素衍生物对癌症进行mTOR靶向治疗。
Ann Oncol. 2005 Apr;16(4):525-37. doi: 10.1093/annonc/mdi113. Epub 2005 Feb 22.

ScFKBP12 在拟南芥中连接雷帕霉素和 AtTOR。

ScFKBP12 bridges rapamycin and AtTOR in Arabidopsis.

机构信息

Biotechnology Research Institute; Chinese Academy of Agricultural Sciences; Beijing, PR China.

School of Life Sciences; Chongqing University; Chongqing, PR China.

出版信息

Plant Signal Behav. 2013 Nov;8(11):e26115. doi: 10.4161/psb.26115. Epub 2013 Aug 29.

DOI:10.4161/psb.26115
PMID:23989449
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4106506/
Abstract

FKBP12 encodes a prolyl isomerase and highly conserved in eukaryotic species. In yeasts and animals, FKBP12 can interact with rapamycin and FK506 to form rapamycin-FKBP12 and FK506-FKBP12 complex, respectively. In higher plants, FKBP12 protein lost its function to bind rapamycin and FK506. Early studies showed that yeast and human FKBP12 protein can restore the rapamycin sensitivity in Arabidopsis, but the used concentration is 100-1000 folds higher than that in yeast and animals. High concentration of drugs would increase the cost and cause the potential secondary effects on plant growth and development. Here we further discovered that BP12 plants generated in our previous study are hypersensitive to rapamycin at the concentration as low as that is effective in yeast and animals. It is surprising to observe that WT and BP12 plants are not sensitive to FK506 in normal growth condition. These findings advance the current understanding of rapamycin-TOR signaling in plants.

摘要

FKBP12 编码一种脯氨酰异构酶，在真核生物中高度保守。在酵母和动物中，FKBP12 可以分别与雷帕霉素和 FK506 相互作用，形成雷帕霉素-FKBP12 和 FK506-FKBP12 复合物。在高等植物中，FKBP12 蛋白失去了与雷帕霉素和 FK506 结合的功能。早期研究表明，酵母和人类 FKBP12 蛋白可以恢复拟南芥中雷帕霉素的敏感性，但所用浓度比酵母和动物高 100-1000 倍。高浓度的药物会增加成本，并对植物的生长和发育产生潜在的副作用。在这里，我们进一步发现，在我们之前的研究中生成的 BP12 植物对雷帕霉素的敏感性在低浓度下就像在酵母和动物中那样有效。令人惊讶的是，在正常生长条件下，WT 和 BP12 植物对 FK506 不敏感。这些发现推进了我们对植物中雷帕霉素-TOR 信号的理解。