De Nisi A, Scotto G, De Mattei G F, Vernazzani A, Saggese M P, Sommariva S, Podestà A
Divisione di Chirurgia Generale, USSL n. 18 Tigullio Orientale, Lavagna, Genova.
Minerva Chir. 1990 Jun 15;45(11):813-20.
Recurrent calculi of the main bile way may be recurrent or residual. Recurrent stones are yellow-brown, crumbly and earthy and contain high quantities of calcium palmitate; residual stones, on the other hand, are firmer, round or berry-like, usually faceted and contain cholesterol, bilirubinate and carbonate of calcium (aragonite, vaterite, etc.) but never palmitate. Residual stones at times also present a peripheral "shell" presenting palmitate and this shows that a new component determined by bile changes is added to the cholesterol stone, which represents the central core, because of stasis and biliary infection. The distinction of calculi into residual and recurrent is also made on the basis of the classic morphologic and clinical criteria described in the literature, also and above all on the basis of specific, objective scientific criteria deriving from in-depth clinical study of the patient, the chemical study of the bile, morphological, mineralogical and structural study of the stone. The following are considered in particular: instrumental examinations made during hospitalisation and operation; pH, enzymatic activity (phospholipase, trypsin and amylase) and examination of bile cultures; morphological, microscopic examination (electronic scan microscopy) and mineralogical examination (X-ray diffractometry and infrared spectroscopy) of the calculus. A personal series of recurrent calculosis of the main biliary way is considered, special attention being paid to a case that was particularly interesting in relation to the fact lithiasic recurrence occurred just 10 months after the previous operation and the fact that biliary stasis was not determined by stenosis of the papilla which proved fully patent.
主胆管复发性结石可能是复发性的或残留性的。复发性结石呈黄褐色,易碎且质软,含有大量棕榈酸钙;而残留结石则更硬,呈圆形或浆果状,通常有刻面,含有胆固醇、胆红素钙和碳酸钙(文石、球霰石等),但从不含有棕榈酸钙。残留结石有时还会有一层含棕榈酸钙的外周“壳”,这表明由于胆汁淤积和胆道感染,由胆汁变化决定的一种新成分添加到了以胆固醇结石为核心的结石中。结石分为残留性和复发性也是基于文献中描述的经典形态学和临床标准,尤其是基于对患者进行深入临床研究、胆汁化学研究、结石形态学、矿物学和结构研究得出的特定客观科学标准。特别要考虑以下几点:住院和手术期间进行的器械检查;胆汁的pH值、酶活性(磷脂酶、胰蛋白酶和淀粉酶)以及胆汁培养检查;结石的形态学、显微镜检查(电子扫描显微镜)和矿物学检查(X射线衍射法和红外光谱法)。本文考虑了一系列主胆管复发性结石病例,特别关注了一个特别有趣的病例,该病例中上一次手术后仅10个月就发生了结石复发,而且胆管淤积并非由完全通畅的乳头狭窄所致。