National Heart, Lung and Blood Institute, National Institutes of Health, Building 10, Room 2C145, Bethesda, MD, 20892, USA,
Curr Infect Dis Rep. 2013 Oct;15(5):385-93. doi: 10.1007/s11908-013-0351-3.
The Surviving Sepsis Campaign (SSC) sepsis care bundles have recently been revised. The original 6-h resuscitation bundle which included rapid antibiotic administration and hemodynamic support with early goal-directed therapy (EGDT) has been divided into two bundles; one including antibiotic and fluid support to be completed within 3 h, and the other including vasopressor support and measures of central venous pressure and oxygen saturation to be completed within 6 h. The original 24-h management bundle targeting glucose control, administration of corticosteroids and recombinant human activated protein C (rhAPC), and limitation of plateau airway pressures during mechanical ventilation is no longer recommended. Past and recent reports by the SSC and others have suggested that compliance with the original bundles was low and their impact unclear. Examination of the revised bundles in the context of issues and questions arising with the original ones suggest that while compliance with new 3-h bundle will be high, compliance with the 6-h bundle will continue to be low.
拯救脓毒症运动（SSC）的脓毒症护理包最近进行了修订。原有的 6 小时复苏捆绑包包括快速抗生素治疗和早期目标导向治疗（EGDT）的血流动力学支持，现已分为两个捆绑包；一个包括抗生素和液体支持，应在 3 小时内完成，另一个包括血管加压素支持和中心静脉压和氧饱和度的措施，应在 6 小时内完成。针对血糖控制、皮质激素和重组人激活蛋白 C（rhAPC）的给药以及机械通气时平台气道压力限制的原始 24 小时管理捆绑包不再推荐。SSC 及其他组织过去和最近的报告表明，对原始捆绑包的遵守情况较低，其影响尚不清楚。根据原始捆绑包出现的问题和疑问，对修订后的捆绑包进行检查表明，虽然新的 3 小时捆绑包的遵守率会很高，但 6 小时捆绑包的遵守率仍将很低。
