Martinez F D, Taussig L M, Morgan W J
Department of Pediatrics, Children's Research Center, University of Arizona College of Medicine, Tucson.
Pediatr Pulmonol. 1990;9(2):91-5. doi: 10.1002/ppul.1950090206.
We studied maximal expiratory flows at functional residual capacity (VmaxFRC) obtained by use of the chest compression technique in 9 infants who had signs of upper respiratory illness (URI) at the time of testing, and in 9 infants who were symptom-free but whose parents reported they had a URI in the previous month. When compared to 109 infants with no URI, infants with current URI had 40% lower VmaxFRC (mean +/- SD: 125.7 +/- 54.5 mL/s vs. 73.6 +/- 53.6 mL/s; P less than 0.01). Infants with a past URI had mean values for VmaxFRC (120.2 +/- 50.2 mL/s) that were not significantly different from those of infants with no URI. Changes in the shape of the flow-volume loop analogous to those reported in infants with lower airway obstruction were also noticed in infants with current URI. These findings suggest that, as in older children and adults, clinically unapparent alterations in lower airway function occur during URI in infants.
我们对9名在测试时患有上呼吸道疾病（URI）体征的婴儿以及9名无症状但父母报告其在前一个月患过URI的婴儿，使用胸部按压技术测量了功能残气量时的最大呼气流量（VmaxFRC）。与109名无URI的婴儿相比，当前患有URI的婴儿的VmaxFRC降低了40%（平均值±标准差：125.7±54.5毫升/秒 vs. 73.6±53.6毫升/秒；P<0.01）。过去患过URI的婴儿的VmaxFRC平均值（120.2±50.2毫升/秒）与无URI的婴儿没有显著差异。在当前患有URI的婴儿中也注意到了类似于下气道阻塞婴儿所报告的流量-容积环形状的变化。这些发现表明，与大龄儿童和成人一样，婴儿在患URI期间下气道功能会出现临床上不明显的改变。
