Pediatric Pulmonary Unit, The Edmond and Lili Safra Children's Hospital, Sheba Medical Center, Ramat-Gan, Israel; Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
Pediatric Pulmonary Unit, Meyer Children's Hospital, Rambam Medical Center, Haifa, Israel.
Chest. 2011 Jun;139(6):1439-1444. doi: 10.1378/chest.10-0625. Epub 2010 Oct 7.
Reference values for maximal expiratory flows throughout childhood have been developed for each age group, but it remains a challenge to find a single outcome measure that can be tracked from birth to childhood. We believe that maximal flow at functional residual capacity (FRC) (VmaxFRC) may be a good candidate. The aim of this article was to explore the possible use of VmaxFRC as a continuous measure in healthy infants and children of preschool age.
Original spirometric data from healthy infants and preschool children in previously published studies from four centers around the world were reanalyzed (N = 242; ages 0-7 years). In preschool children, VmaxFRC was extracted by reanalysis of available records. Multiple regression analysis was applied to find the best correlation between VmaxFRC and height, weight, and/or age. VmaxFRC values were also compared with previously published data from healthy populations of similar ages.
VmaxFRC highly correlated with height from infancy to childhood: Ln{VmaxFRC [L/s]} = -11.99 + (2.561 × Ln{Length[cm]}), where Ln is natural logarithm; r = 0.90; SE = 0.355; P < .0001. Adding weight but not age improved the correlation slightly (r = 0.91). VmaxFRC values were not affected by sex, maneuver modality (passive or voluntary), body posture, or degree of sedation. We found very good agreement between our calculated VmaxFRC values and the extrapolated VmaxFRC values from reference data of similar and older populations.
VmaxFRC can be easily extracted from spirometry and can potentially serve as a continuous spirometric parameter for describing maximal flow at low lung volumes. Further studies are needed to confirm VmaxFRC values in a wider age range in health and disease.
已经为每个年龄组制定了儿童期最大呼气流量的参考值，但要找到一种可以从出生到儿童期进行跟踪的单一结果衡量标准仍然是一个挑战。我们认为功能残气容量（FRC）时的最大流量（VmaxFRC）可能是一个很好的候选者。本文的目的是探讨 VmaxFRC 作为健康婴儿和学龄前儿童的连续测量指标的可能性。
重新分析了来自世界各地四个中心的先前发表的健康婴儿和学龄前儿童的原始肺活量数据（N = 242；年龄 0-7 岁）。在学龄前儿童中，通过重新分析可用记录提取了 VmaxFRC。应用多元回归分析来寻找 VmaxFRC 与身高、体重和/或年龄之间的最佳相关性。还将 VmaxFRC 值与相似年龄的健康人群的先前发表数据进行了比较。
VmaxFRC 与婴儿期到儿童期的身高高度相关：Ln{VmaxFRC [L/s]} = -11.99 +（2.561×Ln{Length[cm]}），其中 Ln 为自然对数；r = 0.90；SE = 0.355；P <.0001。添加体重而不是年龄略微改善了相关性（r = 0.91）。VmaxFRC 值不受性别、操作方式（被动或主动）、身体姿势或镇静程度的影响。我们发现，我们计算的 VmaxFRC 值与类似和更大年龄人群的参考数据推断的 VmaxFRC 值非常吻合。
VmaxFRC 可以从肺活量测定中轻松提取，并且可以作为描述低肺容量时最大流量的连续肺活量参数。需要进一步的研究来确认健康和疾病人群中更广泛年龄范围内的 VmaxFRC 值。
