Pathology Unit, National Cancer Institute, Pascale Foundation, Naples, Italy;
J Thorac Dis. 2013 Aug;5(4):E155-7. doi: 10.3978/j.issn.2072-1439.2013.07.02.
Malignant peripheral nerve sheath tumors (MPNSTs) are sarcomas originating from the cells constituting the nerve sheaths such as Schwann cells, perineural cells or fibroblasts. They represent approximately 5-10% of all soft tissue sarcomas. They have been rarely observed in the lung. We describe a rare case of primary lung MPNST in an elderly male patient, in which surgical approach has obtained a good control of the disease. Immuno-histochemical and molecular analyses have been required on the surgical specimen due to inadequate possibility of recognition through morphology alone.
恶性外周神经鞘瘤（MPNST）是起源于神经鞘细胞（如施万细胞、神经周围细胞或成纤维细胞）的肉瘤。它们约占所有软组织肉瘤的 5-10%。在肺部很少见。我们描述了一例老年男性患者的肺部原发性 MPNST 罕见病例，该患者通过手术方法获得了疾病的良好控制。由于仅凭形态学识别的可能性不足，因此需要对手术标本进行免疫组织化学和分子分析。
