Cao Y, Minhas V, Tan X, Huang J, Wang B, Zhu M, Gao Y, Zhao T, Yang L, Wood C
Nebraska Center for Virology and the School of Biological Sciences, University of Nebraska-Lincoln, Lincoln, NE, USA; Hangzhou Normal University, Hangzhou, China.
Clin Microbiol Infect. 2014 May;20(5):475-81. doi: 10.1111/1469-0691.12340. Epub 2013 Aug 28.
In China, KSHV seroprevalence varies considerably among different regions and ethnicities. But in Xinjiang province, located in the northwestern China, there is a very high seroprevalence of KSHV in adults of Kazak and Ughur ethnicities. However, KSHV prevalence in children and the risk factors associated with the acquisition of infection are currently not known. The aim of this study was to investigate the prevalence of KSHV infection and identify associated socioeconomic or behavioural risk factors and the humoral immune response among children in this population. This is a cross-sectional study (N = 178) to screen children and their caregivers from Xinjiang for total KSHV antibodies, KSHV neutralizing antibodies and HIV infection. Structured questionnaires were utilized to investigate risk factors associated with KSHV prevalence. KSHV seroprevalence in children and caregivers in Xinjiang was 48.3% and 64.7%, respectively. Neutralizing antibody was detected in most seropositive caregivers (93.8%) but was detected in only 5.8% of the infected children. A significant association was observed between child KSHV seroprevalence and sharing of food among family members. These results suggest that similar to other endemic areas in Africa, KSHV infection in the minority populations of Xinjiang is likely to be occurring during early childhood, probably via horizontal transmission through saliva, and results in high seroprevalence in the adult population.
在中国，卡波西肉瘤相关疱疹病毒（KSHV）的血清流行率在不同地区和民族中差异很大。但在中国西北部的新疆维吾尔自治区，哈萨克族和维吾尔族成年人中KSHV的血清流行率非常高。然而，目前尚不清楚儿童中KSHV的流行情况以及与感染获得相关的危险因素。本研究的目的是调查该人群中儿童KSHV感染的流行情况，确定相关的社会经济或行为危险因素以及体液免疫反应。这是一项横断面研究（N = 178），对来自新疆的儿童及其照顾者进行KSHV总抗体、KSHV中和抗体及HIV感染筛查。采用结构化问卷调查与KSHV流行相关的危险因素。新疆儿童及其照顾者的KSHV血清流行率分别为48.3%和64.7%。大多数血清阳性的照顾者（93.8%）检测到中和抗体，但仅5.8%的感染儿童检测到中和抗体。观察到儿童KSHV血清流行率与家庭成员之间食物共享之间存在显著关联。这些结果表明，与非洲其他流行地区类似，新疆少数民族人群中的KSHV感染可能在儿童早期发生，可能通过唾液水平传播，导致成年人群中的高血清流行率。
