Singer P, Moritz V, Wirth M, Berger I, Forster D
Central Institute for Cardiovascular Research, Academy of Sciences of the GDR, Berlin-Buch.
Prostaglandins Leukot Essent Fatty Acids. 1990 May;40(1):17-20. doi: 10.1016/0952-3278(90)90110-7.
Spontaneously hypertensive rats (SHR) at 4 weeks of age were fed a diet supplemented with sunflowerseed oil (SO), evening primrose oil (EPO), fish oil (FO) or EPO + FO for 22 weeks. A diet with commercially available pellets served as control. Systolic blood pressure was significantly lower during and after FO, EPO and EPO + FO, whereas the lower level after SO was not significant when compared with the controls. Serum triglycerides and total cholesterol were lowest after EPO followed FO. The combination of both EPO and FO resulted in unexpected high values of triglycerides and cholesterol. HDL-cholesterol was likewise highest after EPO + FO. The results indicate a quantitatively different depression of blood pressure and serum lipids from SHR by individual polyunsaturated fatty acids (PUFA).
