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Bioorg Med Chem Lett. 2013 Oct 15;23(20):5471-83. doi: 10.1016/j.bmcl.2013.08.003. Epub 2013 Aug 11.
Multiple technologies have emerged for structural diversification and efficient production of metabolites of drug molecules. These include expanded use of enzymatic and bioorganic transformations that mimic biological systems, biomimetic catalysis and electrochemical techniques. As this field continues to mature the breadth of transformations is growing beyond simple oxidative processes due in part to parallel development of more efficient catalytic methods for functionalization of unactivated scaffolds. These technologies allow for efficient structural diversification of both aromatic and aliphatic substrates in many cases via single step reactions without the use of protecting groups.
多种技术已经出现，用于药物分子的代谢物的结构多样化和高效生产。这些技术包括扩大使用模拟生物系统的酶和生物有机转化、仿生催化和电化学技术。随着这一领域的不断成熟，转化的范围正在扩大，超出了简单的氧化过程，部分原因是为未活化支架的功能化开发了更有效的催化方法。这些技术允许在许多情况下通过单步反应而无需使用保护基团，对芳香族和脂肪族底物进行高效的结构多样化。
