Department of Microbiology & Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, Victoria 3010, Australia.
Curr Opin Immunol. 2013 Oct;25(5):653-9. doi: 10.1016/j.coi.2013.07.010. Epub 2013 Aug 29.
The diverse αβ T cell receptor (TCR) repertoire exhibits versatility in its ability to generate antigen (Ag) receptors capable of interacting with polymorphic Major Histocompatibility Complex (MHC) molecules and monomorphic MHC-I like molecules, including the CD1 and MR1 families. Collectively, these evolutionarily related Ag-presenting molecules present peptides, lipids and vitamin B metabolites for T cell surveillance. Interestingly, whilst common TCR gene usage can underpin recognition of these distinct classes of Ags, it is unclear whether the 'rules' that govern αβTCR-Ag MHC interactions are shared. We highlight recent observations in the context of TCR biases towards MHC and MHC-I like molecules.
多样性的 αβ T 细胞受体 (TCR) 库在生成抗原 (Ag) 受体的能力方面表现出多样性，这些受体能够与多态性主要组织相容性复合体 (MHC) 分子和单态 MHC-I 样分子相互作用，包括 CD1 和 MR1 家族。这些进化相关的 Ag 呈递分子共同呈现肽、脂质和维生素 B 代谢物供 T 细胞监测。有趣的是，虽然常见的 TCR 基因使用可以支持对这些不同类别的 Ag 的识别，但尚不清楚支配 αβTCR-Ag MHC 相互作用的“规则”是否共享。我们在 TCR 偏向 MHC 和 MHC-I 样分子的背景下强调了最近的观察结果。
