Department of Chemistry, Jinan University, Guangzhou 510632, China.
Bioorg Med Chem Lett. 2013 Oct 15;23(20):5727-32. doi: 10.1016/j.bmcl.2013.07.073. Epub 2013 Aug 8.
Organogermanium(IV) (Ge) is considered to play an important role in the anti-oxidative activities of some Chinese medicines. Here, a new chrysin-organogermanium (Chry-Ge) complex was synthesized and investigated for its potential biological activities. The radicals-sensitive Ge-O bond was introduced to Chry-Ge complex to enhance bioactivities of organic Ge or Chry. Results showed that Chry-Ge complex possessed great anti-oxidative activities, showing stronger hydroxyl scavenging effects than their corresponding ligands. We also demonstrated Chry-Ge complex inhibited ROS-dependent oxidative damage in cells. Moreover, the morphological and biophysical recoveries in oxidation-damaged cells induced by Chry-Ge complex were characterized by atomic force microscopy. All these results collectively suggested that Chry-Ge complex has synergetic effect for radicals scavenging and could be served as promising pharmacologically active agent against anti-oxidative treatment.
有机锗（IV）（Ge）被认为在一些中药的抗氧化活性中发挥重要作用。在这里，我们合成了一种新的白杨素-有机锗（Chry-Ge）配合物，并研究了其潜在的生物学活性。向 Chry-Ge 配合物中引入了对自由基敏感的 Ge-O 键，以增强有机 Ge 或 Chry 的生物活性。结果表明，Chry-Ge 配合物具有很强的抗氧化活性，对羟自由基的清除效果强于其相应的配体。我们还证明了 Chry-Ge 配合物可以抑制 ROS 依赖性的细胞氧化损伤。此外，原子力显微镜还对 Chry-Ge 配合物诱导的氧化损伤细胞的形态和生物物理恢复进行了表征。所有这些结果都表明 Chry-Ge 配合物具有清除自由基的协同作用，可作为一种有前途的抗氧化治疗药物。
