Biochemistry Division, Chemistry Department, Faculty of Science, Tanta University, Tanta, 31527, Egypt.
Eur J Med Res. 2022 Sep 8;27(1):172. doi: 10.1186/s40001-022-00803-y.
Pancreatic adenocarcinoma (PDAC) and lung cancer are expected to represent the most common cancer types worldwide until 2030. Under typical conditions, mitochondria provide the bulk of the energy needed to sustain cell life. For that inhibition of mitochondrial complex ΙΙ (CΙΙ) and ubiquinone oxidoreductase with natural treatments may represent a promising cancer treatment option. A naturally occurring flavonoid with biological anti-cancer effects is chyrsin. Due to their improved bioavailability, penetrative power, and efficacy, chitosan-chrysin nano-formulations (CCNPs) are being used in medicine with increasing frequency. Chitosan (cs) is also regarded as a highly versatile and adaptable polymer. The cationic properties of Cs, together with its biodegradability, high adsorption capacity, biocompatibility, effect on permeability, ability to form films, and adhesive properties, are advantages. In addition, Cs is thought to be both safe and economical. CCNPs may indeed be therapeutic candidates in the treatment of pancreatic adenocarcinoma (PDAC) and lung cancer by blocking succinate ubiquinone oxidoreductase.
预计到 2030 年，胰腺导管腺癌（PDAC）和肺癌将成为全球最常见的癌症类型。在典型条件下，线粒体提供维持细胞生命所需的大部分能量。因此，用天然药物抑制线粒体复合物 II（CII）和泛醌氧化还原酶可能是一种有前途的癌症治疗选择。白杨素是一种具有生物抗癌作用的天然类黄酮。由于其生物利用度、穿透力和功效得到了改善，壳聚糖-白杨素纳米制剂（CCNPs）在医学中的应用越来越频繁。壳聚糖（CS）也被认为是一种多功能、适应性强的聚合物。CS 的阳离子特性及其生物降解性、高吸附能力、生物相容性、对通透性的影响、成膜能力和粘附特性都是其优势。此外，CS 被认为是安全和经济的。CCNPs 通过抑制琥珀酸泛醌氧化还原酶，可能成为治疗胰腺导管腺癌（PDAC）和肺癌的治疗候选药物。
