Gepner P, Botto H, Piette A M, Graveleau P, Chapman A
Service de Médecine Interne, CMC Foch, Suresnes.
Rev Med Interne. 1990 Mar-Apr;11(2):165-7. doi: 10.1016/s0248-8663(05)82222-2.
Clinical, usually moderate myopathy, frequently develops in patients with hypothyroidism and may reveal the thyroid dysfunction. Biological signs of myolysis, essentially a, usually moderate, rise in creatine phosphokinase plasma levels, are often found. On the other hand, rhabdomyolysis seems to be exceptional in this context. We report a case where an extremely severe clinical and biological myopathy associated with transient renal failure revealed hypothyroidism due to prolonged intake of amiodarone.
临床症状通常为中度肌病,常见于甲状腺功能减退患者,且可能提示甲状腺功能障碍。常可发现肌溶解的生物学指标,主要是血浆肌酸磷酸激酶水平通常呈中度升高。另一方面,横纹肌溶解在这种情况下似乎较为罕见。我们报告一例因长期服用胺碘酮导致甲状腺功能减退,出现极其严重的临床和生物学肌病并伴有短暂肾衰竭的病例。