Fatih University, Faculty of Science, Department of Biology, B.cekmece, 34500 Istanbul, Turkey.
J Immunol Methods. 2013 Oct 31;396(1-2):8-14. doi: 10.1016/j.jim.2013.08.010. Epub 2013 Aug 29.
Helicobacter pylori infection is the most common human infection where approximately 50% of the world populations are infected. The diagnosis of such infection is mainly done by endoscopy where gastric biopsies are examined for the presence of H. pylori. Such invasive approach is costly, time consuming and generally requires more than one test to confirm the infection. Serology on the other hand is a non-invasive approach that can detect H. pylori exposure. The lateral flow immunoassays (LFIA) support the serological approach and have the advantage of being fast, economic and require no additional equipment or experience. In this review the principles, components of the LFIA, sensitivities and specificities of the commercially available H. pylori test strips were compared and discussed.
幽门螺杆菌感染是最常见的人类感染，世界上约有 50%的人口受到感染。这种感染的诊断主要通过内窥镜进行，通过检查胃活检来确定是否存在幽门螺杆菌。这种有创方法费用高、耗时，通常需要进行多次检测以确认感染。另一方面，血清学检测是一种非侵入性的方法，可以检测到幽门螺杆菌的暴露。侧向流动免疫分析（LFIA）支持血清学检测方法，具有快速、经济的优点，且不需要额外的设备或经验。在这篇综述中，比较和讨论了市售幽门螺杆菌检测试纸的 LFIA 的原理、组成部分、敏感性和特异性。
