Magnusson Ulf, Ljungvall Karl
Division of Reproduction, Department of Clinical Sciences, Swedish University of Agricultural Sciences, P.O. Box 7054, SE-750 07 Uppsala, Sweden.
Swedish Medical Products Agency, P.O. Box 26, SE-751 03 Uppsala, Sweden.
Reprod Toxicol. 2014 Apr;44:23-32. doi: 10.1016/j.reprotox.2013.08.002. Epub 2013 Aug 29.
The scientific literature on altered onset of puberty predominantly involves studies on females. This paper reviews current knowledge on the role of environmental pollutants in dysregulation of male puberty in humans, laboratory rodents and farm animals. The methods used to determine the onset of puberty are well developed in humans and farm animals, and standardized across studies in humans. In laboratory rodents standardized external morphological endpoints are used. There is an increasing weight of evidence from epidemiological studies in humans, as well as from experiments in animals, indicating that environmental pollutants dysregulate puberty in males. Most data are from studies on "classical" persistent environmental pollutants. Assessing the effect of multichemical environmental pollution on dysregulation of puberty in humans is more challenging; further solid epidemiological data would likely contribute most to our understanding, especially if combined with systematically collected field-data from selected wildlife.
关于青春期启动改变的科学文献主要涉及对女性的研究。本文综述了关于环境污染物在人类、实验啮齿动物和农场动物雄性青春期失调中作用的现有知识。在人类和农场动物中,用于确定青春期启动的方法已经很成熟,并且在人类研究中是标准化的。在实验啮齿动物中,使用标准化的外部形态学终点。来自人类流行病学研究以及动物实验的证据越来越多,表明环境污染物会使雄性青春期失调。大多数数据来自对“经典”持久性环境污染物的研究。评估多化学物质环境污染对人类青春期失调的影响更具挑战性;进一步可靠的流行病学数据可能对我们的理解贡献最大,特别是如果与从选定野生动物系统收集的实地数据相结合。