Fernandes Hugo M, Manolitsas Tom P, Jobling Tom W
Department of Gynae-Oncology, Monash Medical Centre, Clayton, Victoria, Australia.
J Low Genit Tract Dis. 2014 Apr;18(2):E43-5. doi: 10.1097/LGT.0b013e3182976219.
Carcinoma of the neovagina is extremely rare, and only one other case has been reported after sex-reassignment surgery. Malignancies seem to be dependent on the original tissue and are thought to be associated with HPV infection or chronic irritation.
A 53-year-old male-to-female transsexual presented 21 years after initial surgery with vaginal discharge that was found to be due to a moderately differentiated squamous cell carcinoma. She was treated with chemoradiation with disease remission; however, she had significant stenosis and narrowing of the neovagina.
The optimum treatment is unclear, although radiation seems to be the most common technique with surgery an alternative. All patients should have regular clinical follow-up provided by a primary treating unit, which includes pelvic examination and cytologic smears. As a minimum, follow-up should occur as per other vaginal malignancies for at least 10 years.
新阴道癌极为罕见，性别重置手术后仅另有一例报告。恶性肿瘤似乎取决于原始组织，被认为与HPV感染或慢性刺激有关。
一名53岁男性变女性的变性者在初次手术后21年出现阴道分泌物，经检查发现是中度分化的鳞状细胞癌所致。她接受了放化疗，病情缓解；然而，她的新阴道出现了严重的狭窄。
最佳治疗方法尚不清楚，尽管放疗似乎是最常用的技术，手术也是一种选择。所有患者都应由主要治疗单位进行定期临床随访，包括盆腔检查和细胞学涂片检查。至少，应按照其他阴道恶性肿瘤的随访要求进行至少10年的随访。
