追踪白色脂肪组织发育、扩张和再生过程中的脂肪生成。
Tracking adipogenesis during white adipose tissue development, expansion and regeneration.
机构信息
Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.
出版信息
Nat Med. 2013 Oct;19(10):1338-44. doi: 10.1038/nm.3324. Epub 2013 Sep 1.
Abstract
White adipose tissue displays high plasticity. We developed a system for the inducible, permanent labeling of mature adipocytes that we called the AdipoChaser mouse. We monitored adipogenesis during development, high-fat diet (HFD) feeding and cold exposure. During cold-induced 'browning' of subcutaneous fat, most 'beige' adipocytes stem from de novo-differentiated adipocytes. During HFD feeding, epididymal fat initiates adipogenesis after 4 weeks, whereas subcutaneous fat undergoes hypertrophy for a period of up to 12 weeks. Gonadal fat develops postnatally, whereas subcutaneous fat develops between embryonic days 14 and 18. Our results highlight the extensive differences in adipogenic potential in various fat depots.
摘要
白色脂肪组织表现出高度的可塑性。我们开发了一种诱导性、永久性标记成熟脂肪细胞的系统，称为 AdipoChaser 小鼠。我们监测了发育过程、高脂肪饮食（HFD）喂养和寒冷暴露期间的脂肪生成。在寒冷诱导的皮下脂肪“褐变”过程中，大多数“米色”脂肪细胞源自新分化的脂肪细胞。在 HFD 喂养期间，附睾脂肪在 4 周后开始脂肪生成，而皮下脂肪则经历长达 12 周的肥大。性腺脂肪在出生后发育，而皮下脂肪在胚胎第 14 天至 18 天之间发育。我们的研究结果强调了不同脂肪组织中脂肪生成潜力的广泛差异。
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