米色脂肪细胞是鼠和人体内一种独特的产热脂肪细胞类型。
Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human.
机构信息
Dana-Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02215, USA.
出版信息
Cell. 2012 Jul 20;150(2):366-76. doi: 10.1016/j.cell.2012.05.016. Epub 2012 Jul 12.
Abstract
Brown fat generates heat via the mitochondrial uncoupling protein UCP1, defending against hypothermia and obesity. Recent data suggest that there are two distinct types of brown fat: classical brown fat derived from a myf-5 cellular lineage and UCP1-positive cells that emerge in white fat from a non-myf-5 lineage. Here, we report the isolation of "beige" cells from murine white fat depots. Beige cells resemble white fat cells in having extremely low basal expression of UCP1, but, like classical brown fat, they respond to cyclic AMP stimulation with high UCP1 expression and respiration rates. Beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone irisin. Finally, we provide evidence that previously identified brown fat deposits in adult humans are composed of beige adipocytes. These data provide a foundation for studying this mammalian cell type with therapeutic potential. PAPERCLIP:
摘要
棕色脂肪通过线粒体解偶联蛋白 UCP1 产生热量，可抵御体温过低和肥胖。最近的数据表明，存在两种不同类型的棕色脂肪：源自 myf-5 细胞谱系的经典棕色脂肪和 UCP1 阳性细胞，这些细胞从非 myf-5 谱系的白色脂肪中出现。在这里，我们从鼠类白色脂肪组织中分离出“米色”细胞。米色细胞在极低的基础 UCP1 表达方面与白色脂肪细胞相似，但与经典棕色脂肪一样，它们对环 AMP 刺激的反应是高 UCP1 表达和呼吸速率。米色细胞的基因表达模式与白色或棕色脂肪不同，并且对多肽激素鸢尾素具有优先敏感性。最后，我们提供的证据表明，先前在成年人体内鉴定的棕色脂肪沉积物由米色脂肪细胞组成。这些数据为研究这种具有治疗潜力的哺乳动物细胞类型提供了基础。
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2
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3
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