Joshua R A
Department of Veterinary Medicine, University of Ibadan, Nigeria.
Vet Parasitol. 1990 Jul;36(3-4):303-9. doi: 10.1016/0304-4017(90)90042-a.
Quantitative methods were adopted to study the course of Trypanosoma congolense infection in mice and goats. The ease of initiating infection with a single organism (clone) was found to show a smooth correlation with the virulence of 24 isolates. Virulence of T. congolense was found to be directly related to the degree of viability of the parasite but inversely proportional to the capacity of the host to limit parasitaemia. Isolates obtained from the goat in the early stage of the infection were found to be highly infective but moderately virulent; subsequent isolates were of low infectivity and low virulence. Organisms obtained at the terminal stage of the infection were highly virulent. Generally, the highly virulent clones produced rapidly high parasitaemia and mortality in the host. The low virulence clones were characterised by low parasitaemia but very pronounced remission of trypanosomaemia.
采用定量方法研究了冈比亚锥虫在小鼠和山羊体内的感染过程。发现用单个生物体（克隆株）引发感染的难易程度与24株分离株的毒力呈平滑相关。发现冈比亚锥虫的毒力与寄生虫的存活程度直接相关，但与宿主限制寄生虫血症的能力成反比。在感染早期从山羊体内获得的分离株具有高感染性但毒力中等；随后获得了低感染性和低毒力的分离株。在感染末期获得的生物体具有高毒力。一般来说，高毒力克隆株在宿主体内迅速产生高寄生虫血症和死亡率。低毒力克隆株的特征是寄生虫血症低，但锥虫血症明显缓解。
