Weber K, Paolini M, Schmitz M, Fischer R, Coppenrath E, Huber R, Reiser M, Mueller-Lisse U G
Department of Radiology, University of Munich, Muenich.
Medical Hospital V, University of Munich, Munich.
Rofo. 2014 Jan;186(1):54-60. doi: 10.1055/s-0033-1350297. Epub 2013 Aug 30.
The semi-quantitative Brody score measures the severity of cystic fibrosis (CF)-related lung disease. We investigated the short-term (28 - 60 days) and long-term (2 - 7 years) intra- and inter-observer reproducibility of the Brody score in low-dose multidetector row computed tomography examinations performed in inspiration (LDCTs) of adult CF patients.
Composite Brody scores and respective underlying bronchiectasis, mucus plugging, peribronchial thickening, parenchymal opacity, and hyperinflation subscores were evaluated twice (time interval, 1 - 84 months) by each of 3 independent radiologists (1 - 20 years of professional diagnostic radiology experience) in LDCTs (4 - 64 rows, 120 KVp, 10 - 15 mAs/slice, CTDIw approx. 1.0 mGy, effective dose approx. 0.5 mSv) of 15 adult patients with CF-related lung disease (8 female, 7 male, age, 18 - 50 years, mean, 33 years).
The average reproducibility of the Brody score was within +/-7 % (range, 2 - 30 %) between radiologists, and +/-6 % (3 - 12 %) within radiologists (short-term, 28 - 60 days, 4 %, 0 - 12 %, long-term, 2 - 7 years, 12 %, 1 - 36 %). For the different subscores, the reproducibility was within +/-25 % (15 - 41 %) between radiologists and +/-23 % (12 - 46 %) within radiologists.
The Brody score shows high average inter-observer reproducibility in LDCTs of adult CF patients. The Brody score also demonstrates high average intra-observer reproducibility if subsequent assessments are made within 28 - 61 days. With time intervals of 2 - 7 years between subsequent evaluations, however, intra-observer reproducibility decreases. Respective subscores each demonstrate lower intra- and inter-observer reproducibility than does the composite Brody score.
半定量布罗迪评分用于衡量囊性纤维化（CF）相关肺部疾病的严重程度。我们研究了在成年CF患者吸气期低剂量多层螺旋CT检查（LDCT）中，布罗迪评分在短期（28 - 60天）和长期（2 - 7年）内的观察者间及观察者内的可重复性。
3名独立放射科医生（具有1 - 20年专业诊断放射学经验）对15例成年CF相关肺部疾病患者（8例女性，7例男性，年龄18 - 50岁，平均33岁）的LDCT（4 - 64排，120 kVp，10 - 15 mAs/层，容积CT剂量指数约1.0 mGy，有效剂量约0.5 mSv）进行两次评估（时间间隔1 - 84个月），评估内容包括综合布罗迪评分及其潜在的支气管扩张、黏液嵌塞、支气管周围增厚、实质密度增高和肺过度充气分项评分。
放射科医生之间布罗迪评分的平均可重复性在±7%（范围2 - 30%）以内，放射科医生自身的平均可重复性在±6%（3 - 12%）以内（短期，28 - 60天，4%，0 - 12%；长期，2 - 7年，12%，1 - 36%）。对于不同的分项评分，放射科医生之间的可重复性在±25%（15 - 41%）以内，放射科医生自身的可重复性在±23%（12 - 46%）以内。
在成年CF患者的LDCT中，布罗迪评分显示出较高的观察者间平均可重复性。如果在28 - 61天内进行后续评估，布罗迪评分也显示出较高的观察者内平均可重复性。然而，后续评估的时间间隔为2 - 7年时，观察者内可重复性会降低。各分项评分的观察者内和观察者间可重复性均低于综合布罗迪评分。
