Kolygin B A, Kobikov S Kh
Vopr Onkol. 1990;36(7):841-5.
Results of treatment of 406 primary cases of Hodgkin's disease aged 2-15 years were retrospectively analysed. Complete remission was registered in 349 (86.0%) patients whereas in 57 (14.0%) partial or no response was observed (resistant forms). The characteristic features of the latter group were: age 10-14 years, short history of disease, primary involvement of the mediastinum, lymphocyte depletion histologic subtype, stage IV, presence of B-symptoms and biologic signs of activity, involvement of mediastinal and bronchopulmonary lymph nodes, 7-9 pathologic sites and bulky (larger than 5 cm in diameter) lesions. Six or more of the above features were observed in 89.5% of resistant patients and as few as 2.6% of complete responders.
对406例年龄在2至15岁的霍奇金病原发性病例的治疗结果进行了回顾性分析。349例（86.0%）患者实现完全缓解，而57例（14.0%）患者出现部分缓解或无反应（耐药型）。后一组的特征为：年龄10至14岁、病程短、纵隔原发性受累、淋巴细胞消减组织学亚型、IV期、存在B症状和生物学活动体征、纵隔和支气管肺淋巴结受累、7至9个病理部位以及巨大（直径大于5厘米）病变。89.5%的耐药患者出现上述六种或更多特征，而完全缓解者中这一比例仅为2.6%。
