Tazhibaev Sh S, Lenskaia E G, Alekseeva N R, Sisemalieva Zh S, Monakhov B V
Vopr Pitan. 1990 May-Jun(3):47-51.
A study was made of the influence of excessive culinary fat in the diet containing 30% of trans-isomers and tocopherol on tumor growth, parameters of antitumor and toxic action of carminomycin, and the state of thiol-dependent defensive systems of the liver. The data obtained have evidenced a negative influence of the experimental ration on the survival of the tumor-carriers and on the condition of the normal animals. Activation of the glutathion S-transferase system attended by the exhaustion of the thiol pool in the liver was recorded. Carminomycin toxic action was not modified by the experimental diet.
研究了饮食中含30%反式异构体和生育酚的过量烹饪脂肪对肿瘤生长、卡米诺霉素的抗肿瘤和毒性作用参数以及肝脏硫醇依赖性防御系统状态的影响。所获数据证明实验日粮对荷瘤动物的存活以及正常动物的状况有负面影响。记录到谷胱甘肽S-转移酶系统的激活伴随着肝脏中硫醇池的耗尽。实验日粮未改变卡米诺霉素的毒性作用。
