[The influence on tumor growth and the function of the thiol-dependent systems of the liver of excess cooking fat and vitamin E in the diet. The effects of carminomycin].

A study was made of the influence of excessive culinary fat in the diet containing 30% of trans-isomers and tocopherol on tumor growth, parameters of antitumor and toxic action of carminomycin, and the state of thiol-dependent defensive systems of the liver. The data obtained have evidenced a negative influence of the experimental ration on the survival of the tumor-carriers and on the condition of the normal animals. Activation of the glutathion S-transferase system attended by the exhaustion of the thiol pool in the liver was recorded. Carminomycin toxic action was not modified by the experimental diet.