[13-腙取代的洋红霉素的抗肿瘤特性的合成与研究]
[Synthesis and study of the antitumor properties of 13-hydrazone-substituted carminomycin].
作者信息
Povarov L S, Olsuf'eva E N, Bazhanov V S, Filippos'iants S T, Shepelevtseva N G
出版信息
Antibiotiki. 1982 Feb;27(2):137-40.
PMID:6895983
Abstract
13-Tret-butoxycarbonyl hydrazone (BOC hydrazone) of carminomycin was prepared by interaction of carminomycin with tret-butoxycarbonyl hydrazine. Interaction of carminomycin with N-amino-N'-methyl piperazine resulted in 13-(4-methyl piperazinyl) imine (MP imine) of carminomycin. BOC hydrazone and MP imine of carminomycin had a significant antiblastomic activity against lymphosarcoma LIO-1. Still, they had no advantages over carminomycin.
摘要
通过柔红霉素与叔丁氧羰基肼相互作用制备了柔红霉素的13-叔丁氧羰基腙（BOC腙）。柔红霉素与N-氨基-N'-甲基哌嗪相互作用生成了柔红霉素的13-（4-甲基哌嗪基）亚胺（MP亚胺）。柔红霉素的BOC腙和MP亚胺对淋巴肉瘤LIO-1具有显著的抗胚细胞瘤活性。然而，它们相对于柔红霉素并无优势。
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