Institute of Materials Research and Engineering, A*STAR (Agency for Science, Technology and Research), 3 Research Link, Singapore, 117602, Singapore; School of Materials Science and Engineering, Nanyang Technological University, Block N4.1, Nanyang Avenue, Singapore, 639798, Singapore.
Macromol Rapid Commun. 2013 Oct;34(19):1563-8. doi: 10.1002/marc.201300529. Epub 2013 Aug 29.
Rocket-like vesicles formed are composed of poly(acrylic aicd) (PMAA )/poly(ethylene glycol) (PEG) complex coated hollow silica spheres, and the structure and composition of the vesicles are characterized using TGA, (1)H NMR, FTIR, and TEM. Although only one-third of EG units of PEG brushes grafted to hollow silica spheres form the complex with PMAA via hydrogen bonding, the first "booster" layer composed of PMAA/PEG complex can provide secure encapsulation of model compound calcein blue under an acidic condition. The second "booster" layer composed of PEG brushes can be formed by changing acidic pH to 7.4 through the disassociation of the PMAA/PEG complex. A higher molecular weight PMAA exhibits a faster disassembly due to the formation of a looser PMAA/PEG complex on the surfaces of hollow silica spheres.
形成的火箭状囊泡由聚（丙烯酸）（PMAA）/聚（乙二醇）（PEG）复合涂层的中空硅球组成，囊泡的结构和组成采用 TGA、（1）H NMR、FTIR 和 TEM 进行表征。尽管只有三分之一的接枝到中空硅球上的 PEG 刷上的 EG 单元通过氢键与 PMAA 形成复合物，但由 PMAA/PEG 复合物组成的第一个“助推器”层可以在酸性条件下安全地包封模型化合物钙黄绿素蓝。第二个“助推器”层由 PEG 刷组成，通过将酸性 pH 值改变为 7.4，可以通过 PMAA/PEG 复合物的解离来形成。由于在中空硅球表面形成了更松散的 PMAA/PEG 复合物，较高分子量的 PMAA 表现出更快的组装解体。
