Department of Mechanical and Manufacturing Engineering, University of Manitoba, Winnipeg, Manitoba; Manitoba Institute of Child Health, Winnipeg, Manitoba, Canada.
Pediatr Pulmonol. 2013 Nov;48(11):1098-111. doi: 10.1002/ppul.22657. Epub 2013 Sep 2.
Nanomedicine is a rapidly emerging technology and represents an innovative field for therapy. Nanomaterials have intrinsically defined features for biomedical applications due to the high specific surface area, the amazing diversity, versatility in structure and function and the possibility of surface charge. In particular, the functionalization of targeting or stimuli-responsive unit on the surface of these materials gives them specific targeted therapeutic properties. There are many pediatric lung diseases that could potentially benefit from nanomedicine. Herein, we aim to review various drug carrier systems and release systems specifically targeting pediatric lung diseases. The injection of nanomedicine into in vivo models and their elimination will also be discussed. Finally, the potential toxicity of nanomaterials will be addressed.
纳米医学是一项快速发展的技术，代表了治疗学的一个创新领域。由于具有高比表面积、惊人的多样性、结构和功能的多功能性以及表面电荷的可能性，纳米材料具有内在的生物医学应用特征。特别是，在这些材料的表面上对靶向或刺激响应单元的功能化赋予了它们特定的靶向治疗特性。有许多儿科肺部疾病可能会受益于纳米医学。在这里，我们旨在综述各种药物载体系统和专门针对儿科肺部疾病的释放系统。还将讨论纳米医学在体内模型中的注射及其消除。最后，将解决纳米材料的潜在毒性问题。
