• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

A型肉毒毒素联合神经动力松动术治疗下肢痉挛:一例报告

Botulinum toxin type A combined with neurodynamic mobilization for lower limb spasticity: a case report.

作者信息

Villafañe Jorge H

机构信息

Physical Therapist, Department of Physical Therapy, Residenza Sanitaria Assistenziale "A. Maritano," Sangano, Italy.

出版信息

J Chiropr Med. 2013 Mar;12(1):39-44. doi: 10.1016/j.jcm.2013.01.001.

DOI:10.1016/j.jcm.2013.01.001
PMID:23997723
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3610952/
Abstract

OBJECTIVE

This case report describes a patient with severe lower limb spasticity treated with botulinum toxin type A (BoNT-A) and neurodynamic mobilization (NM).

CLINICAL FEATURES

An 81-year-old male patient presented with a severe spastic lower limbs after total right hip replacement and severe alcoholic polyneuropathy. After the right hip replacement, he presented with generalized spasticity, crouched posture, and a large sacral pressure sore. The severe spasticity in his knees prevented walking.

INTERVENTION AND OUTCOME

The patient underwent combined treatment with BoNT-A and NM of the lower limb in 4 weekly applications. Evaluations were performed pretreatment, 4 weeks after the injection, and at a follow-up session 9 months after finishing treatment. We measured the following outcomes: pain by the Numerical Rating Scale, spasticity by the Modified Ashworth Scale for Grading Spasticity, acceptance and emotional reaction to the treatment by the Hospital Anxiety and Depression Scale, and functionality by ranges of motion. We found that the patient improved in all of the outcomes after treatment, and these results were maintained during the follow-up. After treatment, the patient was able to improve wound healing by properly positioning himself in bed or on his wheelchair and walking with help. At the follow-up evaluation, the results were maintained. The patient showed good acceptance and decreased anxiety/depression after treatment.

CONCLUSION

For this patient, the combination of NM and BoNT-A treatment decreased pain and spasticity and improved joint ranges of motion.

摘要

目的

本病例报告描述了一名患有严重下肢痉挛的患者,接受了A型肉毒毒素(BoNT-A)和神经动力松动术(NM)治疗。

临床特征

一名81岁男性患者在全右髋关节置换术后出现严重下肢痉挛,并伴有严重酒精性多发性神经病。右髋关节置换术后,他出现全身痉挛、蹲伏姿势和巨大的骶部压疮。他膝盖的严重痉挛妨碍了行走。

干预与结果

患者每周接受一次BoNT-A和下肢NM联合治疗,共4次。在治疗前、注射后4周以及治疗结束后9个月的随访时进行评估。我们测量了以下结果:用数字评定量表评估疼痛,用改良Ashworth痉挛评定量表评估痉挛程度,用医院焦虑抑郁量表评估对治疗的接受度和情绪反应,用关节活动范围评估功能。我们发现患者治疗后的所有结果均有改善,且这些结果在随访期间得以维持。治疗后患者能够通过在床上或轮椅上正确摆放姿势以及在他人帮助下行走来促进伤口愈合。在随访评估时,结果得以维持。患者治疗后表现出良好的接受度,焦虑/抑郁情绪减轻。

结论

对于该患者,NM和BoNT-A联合治疗减轻了疼痛和痉挛,改善了关节活动范围。

相似文献

1
Botulinum toxin type A combined with neurodynamic mobilization for lower limb spasticity: a case report.A型肉毒毒素联合神经动力松动术治疗下肢痉挛:一例报告
J Chiropr Med. 2013 Mar;12(1):39-44. doi: 10.1016/j.jcm.2013.01.001.
2
Botulinum toxin type A combined with neurodynamic mobilization for upper limb spasticity after stroke: a case report.A型肉毒杆菌毒素联合神经动力松动术治疗中风后上肢痉挛:一例报告
J Chiropr Med. 2012 Sep;11(3):186-91. doi: 10.1016/j.jcm.2012.05.009.
3
BoTULS: a multicentre randomised controlled trial to evaluate the clinical effectiveness and cost-effectiveness of treating upper limb spasticity due to stroke with botulinum toxin type A.BoTULS 研究:一项多中心随机对照试验,旨在评估 A 型肉毒毒素治疗脑卒中后上肢痉挛的临床疗效和成本效益。
Health Technol Assess. 2010 May;14(26):1-113, iii-iv. doi: 10.3310/hta14260.
4
The Complex Role of Botulinum Toxin in Enhancing Goal Achievement for Post-Stroke Patients.肉毒毒素在增强中风后患者目标实现中的复杂作用。
Toxins (Basel). 2024 Mar 31;16(4):172. doi: 10.3390/toxins16040172.
5
Botulinum toxin type A for rehabilitation after a spinal cord injury: a case report.A型肉毒杆菌毒素用于脊髓损伤后的康复:一例报告
J Orthop Surg (Hong Kong). 2009 Apr;17(1):96-9. doi: 10.1177/230949900901700121.
6
[Botulinum toxin treatment of hip adductor spasticity in multiple sclerosis].[肉毒杆菌毒素治疗多发性硬化症患者的髋内收肌痉挛]
Wien Klin Wochenschr. 2001;113 Suppl 4:20-4.
7
[Botulinum toxin in the management of spastic hip adductors in non-ambulatory cerebral palsy children].[肉毒杆菌毒素用于治疗非行走型脑瘫儿童的痉挛性髋内收肌]
Rev Chir Orthop Reparatrice Appar Mot. 2002 May;88(3):279-85.
8
Botuloscope: 1-year follow-up of upper limb post-stroke spasticity treated with botulinum toxin.肉毒杆菌镜:采用肉毒毒素治疗脑卒中后上肢痉挛的 1 年随访结果。
Ann Phys Rehabil Med. 2019 Jul;62(4):207-213. doi: 10.1016/j.rehab.2019.06.003. Epub 2019 Jun 20.
9
Botulinum toxin type A combined with cervical spine manual therapy for masseteric hypertrophy in a patient with Alzheimer-type dementia: a case report.A型肉毒毒素联合颈椎手法治疗阿尔茨海默病型痴呆患者咬肌肥大:一例报告
J Chiropr Med. 2012 Dec;11(4):280-5. doi: 10.1016/j.jcm.2012.10.004.
10
Effectiveness of botulinum toxin A for upper and lower limb spasticity in children with cerebral palsy: a summary of evidence.A型肉毒毒素治疗小儿脑瘫上下肢痉挛的有效性:证据总结
J Neural Transm (Vienna). 2009 Mar;116(3):319-31. doi: 10.1007/s00702-008-0175-8. Epub 2009 Jan 14.

引用本文的文献

1
Gait analysis using three-dimensional motion and ground reaction force systems in patients with hemiplegia treated with botulinum toxin type A in ankle plantar flexors.使用三维运动和地面反作用力系统对肉毒杆菌毒素A治疗踝关节跖屈的偏瘫患者进行步态分析。
J Rural Med. 2024 Jul;19(3):174-180. doi: 10.2185/jrm.2024-006. Epub 2024 Jul 1.
2
Acute effects of a single neurodynamic mobilization session on range of motion and H-reflex in asymptomatic young subjects: A controlled study.单次神经动态松动术对无症状年轻受试者关节活动度和 H 反射的急性影响:一项对照研究。
Physiol Rep. 2023 Jun;11(12):e15748. doi: 10.14814/phy2.15748.
3
Effectiveness of Neurodynamic Mobilization versus Conventional Therapy on Spasticity Reduction and Upper Limb Function in Tetraplegic Patients.神经动力松动术与传统疗法对四肢瘫痪患者痉挛减轻及上肢功能的疗效比较
Asian Spine J. 2021 Aug;15(4):498-503. doi: 10.31616/asj.2020.0146. Epub 2020 Oct 19.
4
Efficacy of Short-Term Robot-Assisted Rehabilitation in Patients With Hand Paralysis After Stroke: A Randomized Clinical Trial.短期机器人辅助康复对脑卒中后手部麻痹患者的疗效:一项随机临床试验
Hand (N Y). 2018 Jan;13(1):95-102. doi: 10.1177/1558944717692096. Epub 2017 Feb 16.
5
Manual therapy and neurodynamic mobilization in a patient with peroneal nerve paralysis: a case report.腓总神经麻痹患者的手法治疗与神经动力松动术:一例报告
J Chiropr Med. 2013 Sep;12(3):176-81. doi: 10.1016/j.jcm.2013.10.007.

本文引用的文献

1
Botulinum toxin type A combined with cervical spine manual therapy for masseteric hypertrophy in a patient with Alzheimer-type dementia: a case report.A型肉毒毒素联合颈椎手法治疗阿尔茨海默病型痴呆患者咬肌肥大:一例报告
J Chiropr Med. 2012 Dec;11(4):280-5. doi: 10.1016/j.jcm.2012.10.004.
2
Botulinum toxin type A combined with neurodynamic mobilization for upper limb spasticity after stroke: a case report.A型肉毒杆菌毒素联合神经动力松动术治疗中风后上肢痉挛:一例报告
J Chiropr Med. 2012 Sep;11(3):186-91. doi: 10.1016/j.jcm.2012.05.009.
3
Radial nerve mobilization decreases pain sensitivity and improves motor performance in patients with thumb carpometacarpal osteoarthritis: a randomized controlled trial.桡神经松解术可降低拇指腕掌关节炎患者的疼痛敏感性并改善其运动功能:一项随机对照试验。
Arch Phys Med Rehabil. 2012 Mar;93(3):396-403. doi: 10.1016/j.apmr.2011.08.045. Epub 2012 Jan 2.
4
Inpatient occupational therapists hand-splinting practice for clients with stroke: A cross-sectional survey from Ireland.爱尔兰针对中风患者的住院职业治疗师手部夹板治疗实践:一项横断面调查
J Neurosci Rural Pract. 2011 Jul;2(2):141-9. doi: 10.4103/0976-3147.83579.
5
Short-term effects of neurodynamic mobilization in 15 patients with secondary thumb carpometacarpal osteoarthritis.15例继发性拇指腕掌关节骨关节炎患者接受神经松动术的短期疗效
J Manipulative Physiol Ther. 2011 Sep;34(7):449-56. doi: 10.1016/j.jmpt.2011.05.016. Epub 2011 Jul 22.
6
Exploring expectations for upper-extremity motor treatment in people after stroke: a secondary analysis.探索中风后人群对上臂运动治疗的期望:二次分析。
Am J Occup Ther. 2011 Jul-Aug;65(4):437-44. doi: 10.5014/ajot.2010.000430.
7
Assessing pain in older people with persistent pain: the NRS is valid but only provides part of the picture.评估老年持续性疼痛患者的疼痛:NRS 是有效的,但只能提供部分情况。
J Pain. 2010 Dec;11(12):1259-66. doi: 10.1016/j.jpain.2010.02.025. Epub 2010 Jun 25.
8
Symptomatic upper limb spasticity in patients with chronic stroke attending a rehabilitation clinic: frequency, clinical correlates and predictors.慢性脑卒中患者上肢痉挛的症状:频率、临床相关因素和预测因素。
J Rehabil Med. 2010 May;42(5):453-7. doi: 10.2340/16501977-0545.
9
Time-course and determinants of spasticity during the first six months following first-ever stroke.首次中风后最初 6 个月痉挛的时间进程和决定因素。
J Rehabil Med. 2010 Apr;42(4):296-301. doi: 10.2340/16501977-0509.
10
Botulinum toxin type A in post-stroke lower limb spasticity: a multicenter, double-blind, placebo-controlled trial.A型肉毒毒素治疗脑卒中后下肢痉挛的多中心、双盲、安慰剂对照研究。
J Neurol. 2010 Aug;257(8):1330-7. doi: 10.1007/s00415-010-5526-3. Epub 2010 Apr 1.