Department of Life Sciences, Agricultural Biotechnology Center, National Chung Hsing University, Taichung 402, Taiwan.
Evid Based Complement Alternat Med. 2013;2013:305898. doi: 10.1155/2013/305898. Epub 2013 Aug 20.
Andrographolide is one of the major diterpene lactones found in Andrographis paniculata Nees and exhibits remarkable inhibitory effects on various cancers. In this study, the antipulmonary cancer effects of andrographolide were studied in a lung tumor mouse model induced by human vascular endothelial growth factor A 165 (hVEGF-A165). These results demonstrated that andrographolide significantly reduced the expression of hVEGF-A165 compared with a mock group in the Clara cells of the lungs. In addition, andrographolide also decreased tumor formation by reducing VEGF, EGFR, Cyclin A, and Cyclin B expression on the transcriptional and translational levels. These results indicated that andrographolide treatment on the overexpression of VEGF can arrest the cell cycle, which induced pulmonary tumors in transgenic mice. In conclusion, the antiangiogenesis and chemotherapeutic potential of andrographolide may provide a cure for pulmonary tumors in the future.
穿心莲内酯是穿心莲中发现的主要二萜内酯之一，对多种癌症具有显著的抑制作用。在这项研究中，穿心莲内酯在人血管内皮生长因子 A165（hVEGF-A165）诱导的肺癌小鼠模型中研究了其抗肺癌作用。这些结果表明，与模拟组相比，穿心莲内酯在肺部的克拉拉细胞中显著降低了 hVEGF-A165 的表达。此外，穿心莲内酯还通过降低 VEGF、EGFR、细胞周期蛋白 A 和细胞周期蛋白 B 的转录和翻译水平来减少肿瘤形成。这些结果表明，穿心莲内酯处理可对上调的 VEGF 细胞周期进行阻滞，从而诱导转基因小鼠的肺肿瘤。总之，穿心莲内酯的抗血管生成和化疗潜力可能为未来的肺肿瘤治疗提供一种方法。
