癌症患者外周血样本中免疫抑制性中性粒细胞的检测
Detection of immune suppressive neutrophils in peripheral blood samples of cancer patients.
作者信息
Hao Suyang, Andersen Mary, Yu Hongbo
机构信息
Department of Pathology, UMass Memorial Medical Center and University of Massachusetts Medical School Worcester, MA, USA.
出版信息
Am J Blood Res. 2013 Aug 19;3(3):239-45. eCollection 2013.
Abstract
Neutrophils provide first-line defense against infections and are potent effectors in innate and adaptive immunity. Recently neutrophils have been shown to play important roles in multiple antitumor reactions. A subset of mature neutrophils in human systemic inflammation has been identified as a unique circulating population of myeloid cells, which is capable of inhibiting T cell responses. These neutrophils show unique immunophenotype (CD11c bright/CD62L dim/CD11b bright/CD16 bright). This study reports detection of mature neutrophils with similar immunophenotype in the peripheral blood samples of cancer patients using flow cytometry analysis. This population of neutrophils is not detected in peripheral blood samples of normal controls. Thus this finding suggests the involvement of mature neutrophils in antitumor immunity.
摘要
中性粒细胞为抵御感染提供一线防御，是先天性和适应性免疫中的强效效应细胞。最近研究表明，中性粒细胞在多种抗肿瘤反应中发挥重要作用。在人类全身炎症中，已鉴定出成熟中性粒细胞的一个亚群是一种独特的循环髓样细胞群体，能够抑制T细胞反应。这些中性粒细胞表现出独特的免疫表型（CD11c亮/CD62L暗/CD11b亮/CD16亮）。本研究报告了通过流式细胞术分析在癌症患者外周血样本中检测到具有相似免疫表型的成熟中性粒细胞。在正常对照的外周血样本中未检测到这群中性粒细胞。因此，这一发现提示成熟中性粒细胞参与了抗肿瘤免疫。
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