通过在卡纳塔克邦班加罗尔使用NESTROF检测法，对在初级卫生保健中心接受产前检查门诊的孕妇中β地中海贫血特征的患病率进行研究。

The Prevalence of the Beta Thalassemia Trait among the Pregnant Women who attended the ANC Clinic in a PHC, by using the NESTROF Test in Bangalore, Karnataka.

作者信息

Kulkarni Praveen, Masthi N R Ramesh, Niveditha Sr, Suvarna R

机构信息

Assistant Professor, Department of Community Medicine, JSS Medical College , Mysore, India .

出版信息

J Clin Diagn Res. 2013 Jul;7(7):1414-7. doi: 10.7860/JCDR/2013/5286.3149. Epub 2013 Jul 1.

DOI:10.7860/JCDR/2013/5286.3149

PMID:23998078

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3749648/

Abstract

UNLABELLED

Contaxt: Every year in India 6000 to 8000 children are born with thalassaemia major. The birth of such a child produces considerable physical and economic strain on the affected child, its family and the community at large. Thus, the emphasis must shift from the treatment to the prevention of such births in the future.

AIMS

To find out the prevalence of the Beta Thalassaemia trait among the pregnant women who attended the antenatal clinics in a Primary Health Centre, by using the NESTROF test; to describe the socio-demographic characteristics of the study subjects, to find out the pregnancies which were 'at risk' of delivering babies with Thalassaemia major and to find out the 'awareness' of the pregnant women regarding Thalassaemia.

MATERIAL AND METHODS

This exploratory study was conducted in a PHC which was attached to the Department of Community Medicine of a medical college which was situated in Bangalore, India, for a period of 3 months. All the pregnant women who attended the antenatal clinic and the husbands of the NESTROF positive women were included in the study. The details regarding the sociodemographic characteristics of the women were collected on a structured proforma and the NESTROF test was performed.

RESULTS

Out of the 210 pregnant women who were tested, 18 (8.5%) were thalassaemia carriers. 12 (66.6%) of them were between 20 - 25 years of age. 5 (27.7%) were born out of 2(nd) degree consanguineous marriages. 7 (38.8%) had a history of abortions, among which 6 (33.3%) were in the 1(st) trimesters of their pregnancies. Out of the 18 positive women, 9 (50%) had turned up with their husbands. All of the husbands were negative for the Thalassaemia carrier status. Thus, there was no pregnancy which was at a risk of delivering babies with thalassaemia major. None (100%) of the pregnant women were aware of the disease, thalassaemia.

CONCLUSIONS

The prevalence of the Beta Thalassaemia trait among the pregnant women was 8.5%.

摘要

未标注

背景：在印度，每年有6000至8000名重型地中海贫血患儿出生。这样一个孩子的出生会给患病儿童及其家庭和整个社区带来相当大的身体和经济压力。因此，未来重点必须从治疗转向预防此类出生。

目的

通过使用NESTROF检测，找出在一家初级卫生中心产前诊所就诊的孕妇中β地中海贫血特征的患病率；描述研究对象的社会人口学特征，找出有分娩重型地中海贫血患儿“风险”的妊娠情况，并了解孕妇对地中海贫血的“知晓情况”。

材料与方法

这项探索性研究在印度班加罗尔一所医学院社区医学系附属的一家初级卫生中心进行，为期3个月。所有在产前诊所就诊的孕妇以及NESTROF检测呈阳性女性的丈夫均纳入研究。通过结构化表格收集有关女性社会人口学特征的详细信息，并进行NESTROF检测。

结果

在接受检测的210名孕妇中，18名（8.5%）为地中海贫血携带者。其中12名（66.6%）年龄在20至25岁之间。5名（27.7%）出生于二级近亲婚姻。7名（38.8%）有流产史，其中6名（33.3%）是在妊娠第一孕期流产。在18名阳性女性中，9名（50%）带着丈夫前来。所有丈夫的地中海贫血携带者状态均为阴性。因此，没有妊娠有分娩重型地中海贫血患儿的风险。100%的孕妇都不知道地中海贫血这种疾病。