Goya N, Yanagisawa H, Nakamura R, Toma H
Department of Urology, Tokyo Women's Medical College.
Hinyokika Kiyo. 1990 May;36(5):549-55.
5-FU has been widely used in the treatment of urogenital cancers. The concentration of orally administered 5-FU was investigated in both the serum and prostate of rats and prostatic cancer patients. In the experimental studies rats were divided into two groups. In rats in group 1 (single administration group), after oral administration of 20 mg/kg/day 5-FU, the 5-FU concentration in serum was 0 at 0 min., 0.916 +/- 0.694 at 10 min., 2.000 +/- 1.159 at 20 min., 1.029 +/- 0.570 at 30 min., 0.119 +/- 0.033 at 60 min., 0.020 +/- 0.020 at 2 hr., 0 at 4 hr. and 0 micrograms/ml at 24 hr.; the 5-FU concentration in prostatic tissue as 0 at 0 min., 0.324 +/- 0.190 at 10 min., 0.843 +/- 0.544 at 20 min., 0.469 +/- 0.252 at 30 min., 0.132 +/- 0.027 at 60 min., 0.094 +/- 0.024 at 2 hr., 0.057 +/- 0.020 at 4 hr. and 0 micrograms/g at 24 hr. In rats in group 2 (daily administration group), 20 mg/kg/day 5-FU was orally administered for seven days. On the seventh day, the 5-FU concentration in serum was 0 at 0 min., 1.877 +/- 0.957 at 10 min., 4.091 +/- 2.184 at 20 min., 1.692 +/- 1.033 at 30 min., 0.345 +/- 0.084 at 60 min., 0.036 +/- 0.019 at 2 hr., 0.005 +/- 0.011 at 4 hr. and 0 micrograms/ml at 24 hr.(ABSTRACT TRUNCATED AT 250 WORDS)
5-氟尿嘧啶已广泛应用于泌尿生殖系统癌症的治疗。对大鼠和前列腺癌患者血清及前列腺中口服5-氟尿嘧啶的浓度进行了研究。在实验研究中，大鼠被分为两组。在第1组（单次给药组）大鼠中，口服20毫克/千克/天的5-氟尿嘧啶后，血清中5-氟尿嘧啶浓度在0分钟时为0，10分钟时为0.916±0.694，20分钟时为2.000±1.159，30分钟时为1.029±0.570，60分钟时为0.119±0.033，2小时时为0.020±0.020，4小时时为0，24小时时为0微克/毫升；前列腺组织中5-氟尿嘧啶浓度在0分钟时为0，10分钟时为0.324±0.190，20分钟时为0.843±0.544，30分钟时为0.469±0.252，60分钟时为0.132±0.027，2小时时为0.094±0.024，4小时时为0.057±0.020，24小时时为0微克/克。在第2组（每日给药组）大鼠中，口服20毫克/千克/天的5-氟尿嘧啶，持续7天。在第7天，血清中5-氟尿嘧啶浓度在0分钟时为0，10分钟时为1.877±0.957，20分钟时为4.091±2.184，30分钟时为1.692±1.033，60分钟时为0.345±0.084，2小时时为0.036±0.019，4小时时为0.005±0.011，24小时时为0微克/毫升。（摘要截取自250字）
