Morita M, Hasuda A
Department of TUR, Sendai Social Insurance Hospital.
Hinyokika Kiyo. 1989 Jul;35(7):1261-5.
The penetration of norfloxacin into prostatic tissue was evaluated on 36 patients with benign prostatic hypertrophy. Norfloxacin was administered orally in a dose of 200 mg three times daily for 3 days preoperatively, blood samples were taken simultaneously at the time of tissue sampling. The patients were divided into 2 groups, groups 1 and 2. In group 1, tissue sampling was done after about 17 hours of final administration of the drug. The mean concentration of norfloxacin in prostatic tissue was 0.38 +/- 0.18 micrograms/g and 0.18 +/- 0.09 micrograms/ml in serum. In group 2, sampling was done after 5.5 hours of final administration. The mean concentration of norfloxacin in prostatic tissue was 0.89 +/- 0.32 micrograms/g and 0.49 +/- 0.25 micrograms/ml in serum.
对36例良性前列腺增生患者评估了诺氟沙星在前列腺组织中的渗透情况。术前3天，诺氟沙星按每日3次、每次200mg的剂量口服给药，在组织取样时同时采集血样。患者被分为两组，即第1组和第2组。在第1组中，在最后一次给药约17小时后进行组织取样。前列腺组织中诺氟沙星的平均浓度为0.38±0.18微克/克，血清中为0.18±0.09微克/毫升。在第2组中，在最后一次给药5.5小时后进行取样。前列腺组织中诺氟沙星的平均浓度为0.89±0.32微克/克，血清中为0.49±0.25微克/毫升。
