Zhang Yan, Li Yan, Zhang Rui
Deprtment of Hematology, The First Affiliated Hospilal, China Medical University, Shenyang 110001, Liaoning Province, China.
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2013 Aug;21(4):1083-7. doi: 10.7534/j.issn.1009-2137.2013.04.052.
SPRED1 protein coded by SPRED1 gene, a kind of tumors suppressor, belongs to Sprouty related protein family and mainly distributes in human brain. The activity of SPRED1 is mainly regulated by the tyrosine phosphorylation, which is stimulated by the hemopoietic factors. As an inhibitor of Ras-MAPK and RhoA cell signaling pathways, SPRED1 plays an important role in tumorigenesis and metastasis of solid tumor. Recently, the inactivation of SPRED1 is reported to result in proliferation, survival time extension and induction angiogenesis of AML cells. There is a clue that SPRED1 is highly related to leukemia genesis. Recently our study proved that the expression level of SPRED1 decreased in patients with acute myeloid leukemia (AML). This review summarizes the recent progress of study on the relationship between SPRED1 and AML, so as to explore the pathogenesis of leukemia and provide a new approach for clinical diagnosis.
由SPRED1基因编码的SPRED1蛋白是一种肿瘤抑制因子，属于Sprouty相关蛋白家族，主要分布于人脑。SPRED1的活性主要受酪氨酸磷酸化调节，而酪氨酸磷酸化由造血因子刺激。作为Ras-MAPK和RhoA细胞信号通路的抑制剂，SPRED1在实体瘤的发生和转移中起重要作用。最近有报道称，SPRED1的失活会导致急性髓系白血病（AML）细胞增殖、存活时间延长并诱导血管生成。有线索表明SPRED1与白血病的发生高度相关。最近我们的研究证明，急性髓系白血病（AML）患者中SPRED1的表达水平降低。本文综述了SPRED1与AML关系的最新研究进展，以探讨白血病的发病机制，并为临床诊断提供新途径。
