Haouas Houda
Hematology. 2014 Sep;19(6):311-23. doi: 10.1179/1607845413Y.0000000139. Epub 2013 Nov 25.
Angiogenesis is a word of Greek origin, 'angeio' refers to blood vessel, and genesis refers to creation, meaning the generation of new blood vessels. This process is essential for vertebrate development and plays a key role in human diseases. Angiogenesis is generally understood to be essential for the growth and metastasis of solid tumors and is also important in acute myeloid leukemia (AML).
This review summarizes the essential features of physiological and tumoral angiogenesis and the methods used for their assessment.
Technologies for evaluating angiogenesis in AML are discussed and the prognostic significance of angiogenic factors is considered in the context of optimizing treatment.
As acute myelogenous leukemia and endothelial cells depend on each other for survival and proliferation, therapy directed against several pro-angiogenic factors might help to enhance the AML outcome.
血管生成一词源于希腊语，“angeio”指血管，“genesis”指生成，意为新血管的形成。这一过程对脊椎动物发育至关重要，且在人类疾病中起关键作用。血管生成通常被认为对实体瘤的生长和转移至关重要，在急性髓系白血病（AML）中也很重要。
本综述总结了生理性和肿瘤性血管生成的基本特征及其评估方法。
讨论了评估AML血管生成的技术，并在优化治疗的背景下考虑了血管生成因子的预后意义。
由于急性髓系白血病和内皮细胞在生存和增殖方面相互依赖，针对多种促血管生成因子的治疗可能有助于改善AML的预后。
