患有和未患有阿司匹林不耐受的哮喘患者鼻息肉成纤维细胞中糖皮质激素诱导抗炎基因的缺陷。 - Suppr

Deficient glucocorticoid induction of anti-inflammatory genes in nasal polyp fibroblasts of asthmatic patients with and without aspirin intolerance.

作者信息

Fernández-Bertolín Laura, Mullol Joaquim, Fuentes-Prado Mireya, Alobid Isam, Roca-Ferrer Jordi, Picado César, Pujols Laura

机构信息

Clinical and Experimental Respiratory Immunoallergy, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Centro de Investigaciones Respiratorias en Red de Enfermedades Respiratorias (CIBERes), Barcelona, Spain.

出版信息

J Allergy Clin Immunol. 2013 Nov;132(5):1243-1246.e12. doi: 10.1016/j.jaci.2013.07.010. Epub 2013 Aug 30.

DOI:10.1016/j.jaci.2013.07.010

PMID:23998656

Abstract

摘要

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Deficient glucocorticoid induction of anti-inflammatory genes in nasal polyp fibroblasts of asthmatic patients with and without aspirin intolerance.患有和未患有阿司匹林不耐受的哮喘患者鼻息肉成纤维细胞中糖皮质激素诱导抗炎基因的缺陷。

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Nuclear translocation of the glucocorticoid receptor in fibroblasts of asthmatic patients with nasal polyposis insensitive to glucocorticoid treatment.糖皮质激素受体在糖皮质激素治疗不敏感的哮喘伴鼻息肉患者成纤维细胞中的核转位。

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Gene-expression profiles in human nasal polyp tissues and identification of genetic susceptibility in aspirin-intolerant asthma.人类鼻息肉组织中的基因表达谱及阿司匹林不耐受性哮喘遗传易感性的鉴定

Clin Exp Allergy. 2009 Jul;39(7):972-81. doi: 10.1111/j.1365-2222.2009.03229.x. Epub 2009 Mar 27.

Lower sensitivity of nasal polyp fibroblasts to glucocorticoid anti-proliferative effects.鼻息肉成纤维细胞对糖皮质激素抗增殖作用的敏感性降低。

Respir Med. 2011 Feb;105(2):218-25. doi: 10.1016/j.rmed.2010.08.001. Epub 2010 Sep 9.

Dipeptidyl-peptidase 10 as a genetic biomarker for the aspirin-exacerbated respiratory disease phenotype.二肽基肽酶10作为阿司匹林加重性呼吸道疾病表型的遗传生物标志物。

Ann Allergy Asthma Immunol. 2015 Mar;114(3):208-13. doi: 10.1016/j.anai.2014.12.003. Epub 2015 Jan 13.

Genetic association analysis of CIITA variations with nasal polyp pathogenesis in asthmatic patients.变应性哮喘患者中 CIITA 变异与鼻息肉发病机制的遗传关联分析。

Mol Med Rep. 2013 Mar;7(3):927-34. doi: 10.3892/mmr.2012.1251. Epub 2012 Dec 27.

Aspirin-Exacerbated Respiratory Disease.阿司匹林加重性呼吸道疾病

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Effect of lipopolysaccharide on glucocorticoid receptor function in control nasal mucosa fibroblasts and in fibroblasts from patients with chronic rhinosinusitis with nasal polyps and asthma.脂多糖对正常鼻黏膜成纤维细胞、伴鼻息肉和哮喘的慢性鼻-鼻窦炎患者的成纤维细胞中糖皮质激素受体功能的影响。

PLoS One. 2015 May 5;10(5):e0125443. doi: 10.1371/journal.pone.0125443. eCollection 2015.

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Deficient glucocorticoid induction of anti-inflammatory genes in nasal polyp fibroblasts of asthmatic patients with and without aspirin intolerance.

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