神经代谢障碍儿童癫痫的表现和治疗：来自约旦的一系列病例

Manifestations and treatment of epilepsy in children with neurometabolic disorders: a series from Jordan.

机构信息

Department of Pediatrics, Division of Child Neurology, Faculty of Medicine, The University of Jordan, P.O. Box 1612, 11941 Amman, Jordan.

Department of Pediatrics, Faculty of Medicine, The University of Jordan, Jordan.

出版信息

Seizure. 2014 Jan;23(1):10-5. doi: 10.1016/j.seizure.2013.08.006. Epub 2013 Aug 16.

DOI:10.1016/j.seizure.2013.08.006

PMID:23998926

Abstract

PURPOSE

To examine the characteristics of epilepsy in children with neurometabolic disorders to reveal co morbidities and optimal treatment.

METHODS

We retrospectively reviewed the files of children diagnosed with a neurometabolic disorder and treated at Jordan University Hospital between 2001 and 2012. We examined the incidence, age at onset, clinical characteristics, and medical control of epilepsy.

RESULTS

Cases treated (40 boys, 30 girls) included the different categories of neurometabolic diseases. Twenty-nine patients (41.4%) were also diagnosed with epilepsy, with age at seizure onset ranging from 3 days to 7 years. All types of seizures were reported, but generalized tonic-clonic and mixed types were most common (16/29 patients, 55.2%). Patients were on either a single antiepileptic drug (16/29, 55.2%) or multiple drugs (13/29, 44.7%), and most drugs prescribed were older generation anticonvulsants. Complete seizure control was achieved in 19/29 patients (65.5%), partial control in 7/29 (24.1%), and poor or no control in 3/29 (10.3%). EEG recordings were missing from the medical files of 10/29 patients. The first EEG revealed epileptiform activity in 12/19 patients (63.2%) and was normal in 7/19 patients (36.8%).

CONCLUSIONS

Epilepsy was diagnosed in about half of pediatric neurometabolic disease patients, with the majority of seizure cases well controlled.

摘要

目的

研究神经代谢障碍儿童癫痫的特点，揭示共病及最佳治疗方法。

方法

我们回顾性分析了 2001 年至 2012 年在约旦大学医院诊断为神经代谢障碍并接受治疗的儿童患者的病历。我们检查了癫痫的发病率、发病年龄、临床特征和医疗控制情况。

结果

治疗病例（40 名男孩，30 名女孩）包括不同类别的神经代谢疾病。29 名患者（41.4%）还被诊断为癫痫，癫痫发作的年龄从 3 天到 7 岁不等。报告了所有类型的癫痫发作，但全身性强直阵挛性和混合性癫痫发作最常见（29 例患者中有 16 例，55.2%）。患者服用单种抗癫痫药物（29 例患者中有 16 例，55.2%）或多种药物（29 例患者中有 13 例，44.7%），大多数处方药物为第一代抗惊厥药物。29 例患者中 19 例（65.5%）完全控制癫痫发作，7 例（24.1%）部分控制，3 例（10.3%）控制不佳或无控制。29 例患者中有 10 例（34.5%）的医疗记录中缺失脑电图记录。19 例患者中的 12 例（63.2%）首次脑电图显示癫痫样活动，19 例患者中的 7 例（36.8%）脑电图正常。