从细叶勾儿茶中分离得到的五个新降二萜。
Five new degraded diterpenoids from Trigonostemon xyphophylloides.
机构信息
School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, PR China; Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, PR China.
出版信息
Bioorg Med Chem Lett. 2013 Oct 15;23(20):5748-51. doi: 10.1016/j.bmcl.2013.01.112. Epub 2013 Jan 31.
Five new degraded diterpenoids trigoxyphins J-N (1-5), among them trigoxyphins K and L have a novel carbon skeleton, together with four known analogues (6-9) have been obtained from the ethanol extract of the twigs of Trigonostemon xyphophylloides. Compounds 1-5 were evaluated for their cytotoxic activity in vitro against three human tumor cell lines by MTT assay. The results exhibited that Trigoxyphin N (5) showed moderate cytotoxicities against SPC-A-1 and SGC-7901 cancer cell lines.
从黄杨叶钩藤的乙醇提取物中分离得到了 5 个新的降解二萜类化合物 trigoxyphins J-N（1-5），其中 trigoxyphins K 和 L 具有新颖的碳骨架，以及 4 个已知类似物（6-9）。采用 MTT 法测定了化合物 1-5 对 3 个人类肿瘤细胞系的体外细胞毒性。结果表明，trigoxyphin N（5）对 SPC-A-1 和 SGC-7901 癌细胞系表现出中等的细胞毒性。
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