[Secondary osteoporosis or secondary contributors to bone loss in fracture. Effects of oxidative stress on bone metabolism].

Recent years, many reports showed that patients with diabetes mellitus, arteriosclerotic diseases and life style diseases have a higher fracture risk, and one of the reasons about it is an oxidative stress on bone metabolism. Oxidative stress, which is induced by life style diseases, aging and menopause, increases active oxygen production and fracture risk by affecting bone metabolism related cells and bone matrix proteins. Since there are few treatments against oxidative stress, so it is important to search further therapeutic agents. This report gives an outline of the effect of oxidative stress on bone metabolism in some conditions, such as diabetes mellitus, arteriosclerotic diseases, chronic kidney diseases and menopause.