Zhao Dian-Dian, Jiao Pei-Lin, Yu Jing-Jia, Wang Xiao-Jing, Zhao Lin, Xuan Yan, Sun Li-Hao, Tao Bei, Wang Wei-Qing, Ning Guang, Liu Jian-Min, Zhao Hong-Yan
Department of Endocrinology and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao-tong University School of Medicine, Shanghai Clinical Center for Endocrine and Metabolic Disease, Shanghai 310000, China.
Int J Endocrinol. 2016;2016:2528956. doi: 10.1155/2016/2528956. Epub 2016 Feb 28.
Accumulating evidence suggests that oxidative stress is associated with osteoporosis. Serum uric acid (UA) is a strong endogenous antioxidant. Therefore, we investigated the relationship between the serum UA and BMD in Chinese men with T2DM. In this cross-sectional study of 621 men with T2DM, BMDs at lumbar spine (L2-4), femoral neck (FN), and total hip (TH) were measured by dual-energy X-ray absorptiometry (DXA). Serum levels of UA, calcium (Ca), 25-OH vitamin D3 (vitD3), parathyroid hormone (PTH), and creatinine (Cr) were also tested. Data analyses revealed that serum UA levels were positively associated with BMD at all sites (p < 0.05) in men with T2DM after adjusting for multiple confounders. The serum UA levels were positively correlated with body weight (r = 0.322), body mass index (BMI) (r = 0.331), Ca (r = 0.179), and Cr (r = 0.239) (p < 0.001) and were also positively associated with the concentrations of PTH (r = 0.10, p < 0.05). When compared with those in the lowest tertile of UA levels, men with T2DM in the highest tertile had a lower prevalence of osteoporosis or osteopenia (adjusted odds ratio 0.54, 95% confidence interval [CI] 0.31-0.95). These data suggest that higher serum levels of UA are associated with higher BMDs and lower risks of osteoporosis in Chinese men with T2DM.
越来越多的证据表明，氧化应激与骨质疏松症有关。血清尿酸（UA）是一种强大的内源性抗氧化剂。因此，我们研究了中国2型糖尿病男性患者血清UA与骨密度（BMD）之间的关系。在这项对621名2型糖尿病男性患者的横断面研究中，采用双能X线吸收法（DXA）测量腰椎（L2-4）、股骨颈（FN）和全髋（TH）的骨密度。还检测了血清UA、钙（Ca）、25-羟基维生素D3（vitD3）、甲状旁腺激素（PTH）和肌酐（Cr）水平。数据分析显示，在调整多个混杂因素后，2型糖尿病男性患者所有部位的血清UA水平均与骨密度呈正相关（p<0.05）。血清UA水平与体重（r=0.322）、体重指数（BMI）（r=0.331）、Ca（r=0.179）和Cr（r=0.239）呈正相关（p<0.001），也与PTH浓度呈正相关（r=0.10，p<0.05）。与UA水平处于最低三分位数的患者相比，UA水平处于最高三分位数的2型糖尿病男性患者骨质疏松或骨量减少的患病率较低（调整后的优势比为0.54，95%置信区间[CI]为0.31-0.95）。这些数据表明，中国2型糖尿病男性患者血清UA水平较高与较高的骨密度和较低的骨质疏松风险相关。
