Addiction Imaging Research Group, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Campbell Family Mental Health Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Addictions, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Schizophrenia Programs, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
Addiction Imaging Research Group, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
Prog Neuropsychopharmacol Biol Psychiatry. 2014 Jul 3;52:4-8. doi: 10.1016/j.pnpbp.2013.08.012. Epub 2013 Aug 30.
The chronic use of drugs, including psychostimulants such as cocaine and amphetamine, has been associated with low D2/3 dopamine receptor availability, which in turn has been linked to poor clinical outcome. In contrast, recent studies focused on the D3 receptor (a member of the D2-like receptor family) suggest that chronic exposure to stimulant drugs can up-regulate this receptor subtype, which, in preclinical models, is linked to dopamine system sensitization - a process hypothesized to contribute to relapse in addiction. In this mini review we present recent human data suggesting that the D3 receptor may contribute to core features of addiction, and discuss the usefulness of the PET imaging probe [(11)C]-(+)-PHNO in investigating this question.
慢性使用药物，包括可卡因和安非他命等精神兴奋剂，与多巴胺 D2/3 受体的低可用性有关，而多巴胺 D2/3 受体的低可用性又与较差的临床结果有关。相比之下，最近的研究集中在 D3 受体（D2 样受体家族的一员）上，表明慢性暴露于兴奋剂药物可以上调这种受体亚型，在临床前模型中，与多巴胺系统敏化有关——这一过程被假设有助于成瘾的复发。在这篇迷你综述中，我们提出了最近的人类数据，表明 D3 受体可能与成瘾的核心特征有关，并讨论了 PET 成像探针 [(11)C]-(+)-PHNO 在研究这一问题中的有用性。
