Shaaban Hamid, Layne Trevor, Guron Gunwant
Department of Hematology and Oncology, St Michael's Medical Center, Newark, NJ, USA
Department of Hematology and Oncology, St Michael's Medical Center, Newark, NJ, USA.
J Oncol Pharm Pract. 2014 Aug;20(4):302-4. doi: 10.1177/1078155213502569. Epub 2013 Sep 2.
Acute kidney injury is commonly observed in patients with multiple myeloma and other plasma cell dyscrasias. The pathophysiologic causes, however, are varied. We report a case of a severe 'drug reaction with eosinophilia and systemic symptoms' syndrome associated with acute interstitial nephritis in a patient with multiple myeloma likely related to the administration of lenalidomide. This disease entity requires prompt recognition and cessation of the offending drug and often treatment with high-dose corticosteroids.
急性肾损伤常见于多发性骨髓瘤和其他浆细胞发育异常的患者。然而，其病理生理原因多种多样。我们报告了一例严重的“伴有嗜酸性粒细胞增多和全身症状的药物反应”综合征，该综合征与一名多发性骨髓瘤患者的急性间质性肾炎相关，可能与来那度胺的使用有关。这种疾病实体需要迅速识别并停用致病药物，且通常需要用大剂量皮质类固醇进行治疗。
