Department of Chemical and Biomolecular Engineering, The University of Akron, Akron, Ohio 44325, USA.
Chem Commun (Camb). 2013 Oct 18;49(81):9317-9. doi: 10.1039/c3cc44249g.
A new type of apo-Tf functionalized nanochannel is developed to achieve the specific and selective binding and unbinding of Fe(3+) in a multiple and reversible manner via a protein-conformation-gating mechanism. This ion-responsive biomimetic nanochannel provides a simple, robust, and promising model for studying other biological processes.
研究团队开发出一种新型载apo-Tf 的纳米通道，通过蛋白构象门控机制，实现了 Fe(3+) 的特异性和选择性结合与释放，具有多重和可逆的特点。这种对离子响应的仿生纳米通道为研究其他生物过程提供了一个简单、稳健且有前景的模型。
