NCE-Polymer Chemistry Group, Piramal Healthcare Ltd., Mumbai, India.
Small. 2012 Jun 11;8(11):1657-63. doi: 10.1002/smll.201102354. Epub 2012 Mar 21.
A transferrin-conjugated PEG-Fe(3) O(4) nanostructured matrix is developed to explore cellular responses in terms of enhanced cell adhesion, specific interactions between ligands in the matrix and molecular receptors on the cell membrane, comparison of cell shapes on 2D and 3D surfaces, and effect of polymer architecture on cell adhesion. Integration of such advanced synthetic nanomaterials into a functionalized 3D matrix to control cell behavior on surfaces will have implications in nanomedicine.
一种转铁蛋白结合的 PEG-Fe(3) O(4) 纳米结构基质被开发出来，以探索增强细胞黏附、基质中配体与细胞膜上分子受体之间的特异性相互作用、二维和三维表面上细胞形状的比较，以及聚合物结构对细胞黏附的影响。将这种先进的合成纳米材料集成到功能化的 3D 基质中，以控制表面上的细胞行为，这将对纳米医学产生影响。
